Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy.

Nat Neurosci
Publication Year: 
Aswathy Ammothumkandy
Kristine Ravina
Victoria Wolseley
Alexandria N Tartt
Pen-Ning Yu
Luis Corona
Naibo Zhang
George Nune
Laura Kalayjian
J John Mann
Gorazd B Rosoklija
Victoria Arango
Andrew J Dwork
Brian Lee
J A D Smith
Dong Song
Theodore W Berger
Christianne Heck
Robert H Chow
Maura Boldrini
Charles Y Liu
Jonathan J Russin
Michael A Bonaguidi
PubMed link: 
Public Summary: 
This article describes how altered stem cell behavior in the human brain contributes to epilepsy.
Scientific Abstract: 
The hippocampus is the most common seizure focus in people. In the hippocampus, aberrant neurogenesis plays a critical role in the initiation and progression of epilepsy in rodent models, but it is unknown whether this also holds true in humans. To address this question, we used immunofluorescence on control healthy hippocampus and surgical resections from mesial temporal lobe epilepsy (MTLE), plus neural stem-cell cultures and multi-electrode recordings of ex vivo hippocampal slices. We found that a longer duration of epilepsy is associated with a sharp decline in neuronal production and persistent numbers in astrogenesis. Further, immature neurons in MTLE are mostly inactive, and are not observed in cases with local epileptiform-like activity. However, immature astroglia are present in every MTLE case and their location and activity are dependent on epileptiform-like activity. Immature astroglia, rather than newborn neurons, therefore represent a potential target to continually modulate adult human neuronal hyperactivity.