TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.

Chia-Lin Chen, a CIRM predoctoral fellow demonstrated Nanog cooperates with an essential pluripotent signal pathway to activate the epithelial-mesenchymal transition, resulting in formation of cancer stem cells and tumorigenesis.