Tuberculosis is an important cause of severe eye inflammation that can lead to blindness; but, the pathways by which eye harbors tuberculosis bacteria are not clear. There are evidences showing that tuberculosis bacteria can remain dormant within specific cell types in the eye and become reactivated later in life. In this study, we showed, for the first time, that tuberculosis bacteria can get into the retinal pigmented epithelium cells and proliferate slowly inside these cells without killing them. The mechanisms by which tuberculosis bacteria enter retinal pigment epithelium cells and bacteria proliferation rate are compared to those in immune system cells.