Analysis of Candidate Neural Crest Cells Derived from Human ES Cells

Alexey Terskikh
Sanford-Burnham Medical Research Institute
SEED: RS1-00466-1
Status: Active
$759000.00

The SEED Awards are intended to bring new ideas and new investigators into the field of human embryonic stem cell (hESC) research. The 73 awards worth $45,329,918 were approved 2/16/07. You can learn more about the awards by reading the RFA or reading the press release.

Public Abstract (provided by applicant)

Little is known about human Neurla Crest (NC) cells, a transient population of cells briefly present during very early human development; the reason why these cells are extremely difficult to obtain and study. In the model organism NC cells generate an amazing array of tissues, including peripheral and enteric nervous systems, cranial bones and cartilage, some cardiac muscle and virtually all pigmented cells in the body. Abnormalities in NC cells involved in numerous human pathologies including various skeletal syndromes (e.g. Apert syndrome), diseases of nervous system (e.g. Hirschsprung

Statement of benefit to California (provided by applicant)

Abnormalities in neural crest (NC) cells involved in numerous human pathologies including various skeletal syndromes (e.g. Apert syndrome), diseases of nervous system (e.g. Hirschsprung