Download Unit 2

Unit 2: Adult Stem Cells, Homeostasis, and Regenerative Medicine

By Betty Jensen, Alexandra Race, and Laurel Barchas

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Suggested time frame: three to seven class periods

Course level: Biology, AP Biology, Biotechnology, Anatomy/Phys, lower division college Biology

Inquiry teaching: Read how to modify the curriculum for inquiry teaching


Brief Outline of Unit 2 with download links

I. Invitation

A. Readings and discussion of Prometheus myth

B. Identifying cells responsible for regeneration

1. Label invitation question on transparencies
2. AP extension questions

C. Differences between wound healing and regeneration

1. Lecture - video from HHM

i. Download Appendix A: HHMI video "Adult Stem Cells and Regeneration"

2. Student question sheet and teacher version

i. Download Appendix A: student questions [pdf]
ii. Download Appendix A: teacher answer sheet [pdf]

II. Exploration

A. Comparison of adult and embryonic stem cells

1. Animation from Learn Genetics, University of Utah
2. Discussion and location of adult stem cells in the body-with graphic organizer
3. Exploration of totipotent, pluripotent, multipotent cells and differentiation
4. AP extension topics
5. Differences between adult stem cells and progenitor cells

B. Homeostasis

1. Video and discussion questions
2. Describing adult stem cell role in homeostasis
3. Lab- Planaria regeneration video and student questions (download video HERE)

i. Download Appendix B: student questions [pdf]
ii. Download Appendix B: teacher answer sheet [pdf]

4. Wet lab protocol, PowerPoint and handouts-NWABR

C. Regenerative medicine

1. Discussion, teacher lecture on treatment possibilities
2. Jigsaw activity

D. Potential uses of adult stem cells

1. Student research and Double Entry Journal

i. Download Appendix C: double entry journal instructions [pdf]

E. Importance of Clinical Trials

1. Explanation of steps in clinical trials.
2. Clinical trials information chart

i. Download Appendix D: student handout [pdf]
ii. Download Appendix D: teacher version [pdf]

III. Application

A. Regenerative medicine and clinical trials research

1. Research project instructions

i. Download Appendix E: Instructions [pdf]
ii Download Appendix E: Grading rubric [pdf]

2. List of 70+ diseases that stem cells could help heal in the future

i. Download Appendix F: List of 70+ diseases that stem cells could help heal in the future [pdf]

3. Preliminary research forms for I-search

i. Download Appendix G: Blank clinical trials research form [word doc]
ii. Download Appendix G: Sample form [pdf]
iii. Download Appendix G: Actual student logs with I-Search [pdf]

4. Create PowerPoint presentation summarizing clinical trial results for chosen disease

i. Download Appendix H: Example of student ppt presentation HIV
ii. Download Appendix H: Example of student ppt Macular Degeneration
iii. Download Appendix H: Example of student ppt Spinal Cord Injury

B. Creative expressions of understanding of stem cells

1. Essay
2. Cartoon/Storyboard
3. Pamphlet

IV. Assessment

A. Stem Cell Table

1. Download Appendix I: student version
2. Download Appendix I: teacher version

© 2013 California Institute for Regenerative Medicine