Summaries of review for applications to RFA 10-02 Tools and Technologies II

Review Summaries for RFA 10-02: CIRM Tools and Technologies II Awards

The following is a listing of all applications reviewed under RFA 10-02 for CIRM Tools and Technologies II Awards. Applications include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Grants Working Group (GWG). A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.

 
= Recommended for funding  
 
= Not Recommended for funding at this time
Application Number Approval Title Scientific Score
RT2-01965 Approved Editing of Parkinson's disease mutation in patient-derived iPSCs by zinc-finger nucleases 90
RT2-01927 Approved Developing a method for rapid identification of high-quality disease specific hIPSC lines 86
RT2-01920 Approved Use of hiPSCs to develop lead compounds for the treatment of genetic diseases 84
RT2-02064 Approved Homologous recombination in human pluripotent stem cells using adeno-associated virus. 82
RT2-02018 Approved Development of Single Cell MRI Technology using Genetically-Encoded Iron-Based Reporters 82
RT2-02022 Approved Engineering Defined and Scaleable Systems for Dopaminergic Neuron Differentiation of hPSCs 82
RT2-01906 Approved Development of small molecule screens for autism using patient-derived iPS cells 80
RT2-02061 Approved Cellular tools to study brain diseases affecting synaptic transmission 79
RT2-01975 Approved Development and preclinical testing of new devices for cell transplantation to the brain. 79
RT2-01880 Approved Site-specific integration of Lmx1a, FoxA2, & Otx2 to optimize dopaminergic differentiation 78
RT2-02057 Approved Tri-resolution Visualization System for Stem Cells and Tissue Regeneration Monitoring 78
RT2-01893 Approved Magnetic Particle Imaging: A Novel Ultra-sensitive Imaging Scanner for Tracking Stem Cells In Vivo 77
RT2-01889 Approved Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation 76
RT2-01942 Approved Robust generation of induced pluripotent stem cells by a potent set of engineered factors 75
RT2-02040 Approved Use of iPS cells (iPSCs) to develop novels tools for the treatment of spinal muscular atrophy. 74
RT2-01887   Novel non-integrating stem cell-derived rAAV vectors for safe and efficient iPSC induction -
RT2-02060 Approved Antibody tools to deplete or isolate teratogenic, cardiac, and blood stem cells from hESCs 73
RT2-01881 Approved Development of a Hydrogel Matrix for Stem Cell Growth and Neural Repair after Stroke 73
RT2-01913   A novel protein delivery platform to promote stem cell reprogramming and differentiation -
RT2-01962   RT2-01962 Adaptive Optics Two-Photon Microscope for Single Cell Imaging of Stem Cells Embedded in Deep Tissue -
RT2-01939   Hearing loss in-a-dish model for otoprotective and otoregenerative drug development -
RT2-01972   Novel PET/MRI Tools to Increase In Vivo Detection Sensitivity of Transplanted Stem Cells -
RT2-02052 Approved Development and Application of Versatile, Automated, Microfluidic Cell Culture System 71
RT2-01919   RNAs as effectors and sensors of pluripotency and differentiation -
RT2-02068   Developing genetically modified human ES cells to model human cancers -
RT2-02016   Engineered Vault NanoCapsules for Efficient and Safe Non-Viral Production of iPS Cells -
RT2-01985   Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders -
RT2-01917   Assessing the Genome and Sequence Integrity of Cellular Therapeutics -
RT2-01914   Purification of human stem cell populations for transplantation -
RT2-01885   A Label-free, Non-Genetic Method to Purify Stem Cell Derived Cardiomyocytes -
RT2-01884   Light-Triggered Action Potential for the Dynamic Measurement of Cardiomyocyte Physiology -
RT2-02014   A Resource for Human Embryonic Stem Cell Functional Genomics -
RT2-01938   Preparation and Delivery of Clinically Relevant Numbers of Stem Cells Using 3D Hydrogels 62
RT2-01969   Label-free sorting of stem cell-derived cardiomyocytes via electrophysiological phenotype -
RT2-01968   In Vivo Control and Visualization of Stem Cell-Driven CNS Regeneration -
RT2-02048   Generation of Human Induced Pluripotent Stem Cells Using Programmable Nanoparticles -
RT2-01899   Optimized creation of lineage-specific reporter iPS cell lines -
RT2-01997   Differential expansion of human breast cancer stem cells in culture -
RT2-01982   A Vascularized Bioreactor for Cardiovascular Tissue Engineering -
RT2-02004   New Tools for Prospective Isolation of human stem and progenitor cells -
RT2-01951   Efficient Scale-Up Cryopreservation of Human Pluripotent Cells and Their Progeny -
RT2-02033   Depletion of Teratoma-Forming Cells for hESC-Based Transplantation Technologies -
RT2-01940   Barcode-Activated Cell Sorter for Mass Production of FDA-Compliant Transplantable Cells -
RT2-01924   Chemo-mechanical induction of pluripotent stem cell differentiation -
RT2-01894   Scalable differentiation of cardiomyocytes and neural stem cells in suspension culture -
RT2-01867   Novel Biomarkers to Identify Fully Pluripotent Human Stem Cell Lines -
RT2-01898   FDA-compatible imaging technique for in vivo tracking of stem-cell derived chondrocytes -
RT2-01984   Multimodal technology for non-destructive characterization of bioengineered tissues -
RT2-01912   Surface Biomarker Code for Isolation of Cardiac Progenitors and Distinct Cardiac Lineages -
RT2-01860   Derivation of high-purity mature hepatocytes from human pluripotent stem cells -
RT2-01903   High-throughput label-free screening of stem cell differentiation -
RT2-01955   In Vitro Teratoma Assays to Measure hESC Tumorigenicity and Screen for Novel Inhibitors -
RT2-02054   Using Whole-Genome Sequencing Technology in ESC and iPSC for Quality Control Monitoring of Genomic Sequence Variation and Stability -
RT2-02037   Novel phenotypic-reversal screens using core transcriptome in “disease-in-a dish” models -
RT2-01878   Parthenogenetic Stem Cell-Derived Human Cornea Models for In-Vitro Toxicity Testing -
RT2-01934   Development of a low cost, turbulence-free, compact bioreactor for the culture and expansion of stem cells -