| Shared Labs Grant – Enhancing/Expanding SRLs | Craig M. Walsh | Shared Resources Laboratories to Enhance In Vitro Stem Cell Modeling and Training |
$4,000,000 |
| Manufacturing Network Grant | Dr. Aileen J Anderson | The UCI GMP Cell and Gene Therapy Manufacturing Facility |
$2,000,000 |
| Foundation – Discovery Stage Research Projects | Albert La Spada Ph.D. | Role of ataxin-3 polyadenylation site selection in ALS neuron toxicity and disease pathogenesis |
$1,514,416 |
| Foundation – Discovery Stage Research Projects | Dr. Brian J. Cummings | Mapping the spatial and temporal responses of hESC-derived microglia to repeat mild closed head injury to identify therapeutic targets and mechanisms |
$1,339,685 |
| Foundation – Discovery Stage Research Projects | Momoko Watanabe | Generation of cortical organoids with tunable areal identities by spatial engineering of morphogens |
$0 |
| COMPASS Training Grant | Dr. Brian J. Cummings | Research Mentorship Program in Regenerative Medicine Careers for a Diverse Undergraduate Student Body |
$2,729,900 |
| Research Training Grant | Dr. Peter J Donovan | CIRM Scholars Comprehensive Research Training Program |
$5,373,742 |
| Conference – The 2020 Grantee Meeting | Daniela A. Bota | 2020 CIRM Grantee Meeting |
$176,762 |
| Conference – The Alpha Stem Cell Clinic Annual Symposium | Daniela A. Bota | 2023 Alpha Stem Cell Clinic Annual Symposium |
$49,512 |
| Progression Award – Discovery Stage Research Projects | Dr. Brian J. Cummings | Human neural stem cell (hNSC) derived exosomes vs CSC14 hNSCs for the treatment of traumatic brain injury (TBI) |
$202,667 |
| Alpha Stem Cell Clinics Network Expansion | Daniela A. Bota | A hub and spoke community model to equitably deliver regenerative medicine therapies to diverse populations across four California counties |
$8,000,000 |
| Quest – Discovery Stage Research Projects | Dr. Michael Demetriou | CAR T cells targeting abnormal N-glycans for the treatment of refractory/metastatic solid cancers |
$1,414,800 |
| Quest – Discovery Stage Research Projects | Dr. Mathew Mark Blurton-Jones | Transplantation of genetically corrected iPSC-microglia for the treatment of Sanfilippo Syndrome (MPSIIIA) |
$1,083,379 |
| Quest – Discovery Stage Research Projects | Munjal M Acharya | Stem cell-derived extracellular vesicles to reverse radiation-induced brain injury |
$1,064,724 |
| Quest – Discovery Stage Research Projects | Robert F. Hunt | Optimization of a human interneuron cell therapy for traumatic brain injury |
$240,000 |
| Quest – Discovery Stage Research Projects | Dr. Mathew Mark Blurton-Jones | Transplantation of Pluripotent Stem Cell Derived Microglia for the Treatment of Adult-onset Leukoencephalopathy (HDLS/ALSP) |
$214,668 |
| Quest – Discovery Stage Research Projects | Dr. Aileen J Anderson | Generation and in vitro profiling of neural stem cell lines to predict in vivo efficacy for chronic cervical spinal cord injury. |
$1,575,613 |
| Quest – Discovery Stage Research Projects | Dr. Brian J. Cummings | Identification and characterization of the optimal human neural stem cell line (hNSC) for the treatment of traumatic brain injury (TBI) 2.0. |
$1,671,213 |
| Quest – Discovery Stage Research Projects | Leslie M Thompson | hNSC-mediated delivery of ApiCCT1 as a candidate therapeutic for Huntington’s disease |
$1,650,263 |
| Inception – Discovery Stage Research Projects | Janet E Baulch | An exosome-based translational strategy to mitigate Alzheimer’s disease neuropathology |
$157,650 |
| Therapeutic Translational Research Projects | Dr. Aileen J Anderson | A human neural stem cell therapeutic candidate for the treatment of chronic cervical spinal cord injury |
$4,950,024 |
| Therapeutic Translational Research Projects | Dr. Brian J. Cummings | An optimized human neural stem cell line (hNSC) for the treatment of traumatic brain injury (TBI) |
$4,804,737 |
| Therapeutic Translational Research Projects | Dr. Magdalene J Seiler | Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models |
$4,769,039 |
| Conference II | Leslie M Thompson | Advanced Therapies and Stem Cells for Huntington’s disease |
$35,900 |
| Conference II | Dr. Mathew Mark Blurton-Jones | ALSP Community Conference: Insights and Potential of Cell-Based Therapies for the Treatment of Leukodystrophies |
$40,499 |
| Conference II | Olga V Razorenova | UCI Stem Cell Research Center 9th Annual Stem Cell Science Symposium |
$8,366 |
| Conference II | Dr. Leslie M Thompson | Stem Cells for Huntington’s Disease (HD) International (SC4HDI) Conference |
$31,727 |
| Conference II | Dr. LESLIE M Thompson | HD-CARE INAUGURAL SYMPOSIUM |
$1,500 |
| Conference II | Dr. Sidney Golub | Human Research In Times of Controversy: From Stem Cells To Fetal Tissue |
$13,562 |
| Late Stage Preclinical Projects | Kyriacos A Athanasiou | Treatment of the TMJ disc complex |
$6,000,000 |
| Late Stage Preclinical Projects | Dr. Leslie M Thompson | An hESC-derived hNSC Therapeutic for Huntington’s Disease |
$5,635,393 |
| Preclinical Development Awards | Dr. Leslie M Thompson | A hNSC Development Candidate for Huntington’s Disease |
$4,951,623 |
| Tools and Technologies III | Dr. Mathew Mark Blurton-Jones | Optimizing the differentiation and expansion of microglial progenitors from human pluripotent stem cells for the study and treatment of neurological disease. |
$1,147,596 |
| Conference | Dr. Peter J Donovan | Systems Biology of Stem Cells |
$25,000 |
| Conference | Dr. Michelle Khine | UC Systemwide Bioengineering Symposium |
$7,525 |
| Disease Team Planning | Dr. Leslie M Thompson | Huntington’s Disease Team |
$41,953 |
| Disease Team Planning | Dr. Henry John Klassen | Stem cells for neuroprotection of photoreceptors in retinitis pigmentosa |
$23,537 |
| Major Facilities | Dr. Michael V Drake | UC Irvine CIRM Institute |
$27,156,000 |
| Basic Biology V | Dr. Peter J Donovan | Non-invasive live imaging of stem cell signature metabolic states |
$516,366 |
| Basic Biology V | Dr. Lisa A Flanagan | Molecular basis of plasma membrane characteristics reflecting stem cell fate potential |
$994,108 |
| Patent Assistance Fund Awards | Ronnie Hanecak | CIRM Patent Assistance Fund Application – UCI |
$46,155 |
| Early Translational IV | Dr. Magdalene J Seiler | Restoring vision by sheet transplants of retinal progenitors and retinal pigment epithelium (RPE) derived from human embryonic stem cells (hESCs) |
$3,998,948 |
| Disease Team Therapy Development – Research | Dr. Henry John Klassen | Retinal progenitor cells for treatment of retinitis pigmentosa |
$17,144,825 |
| Early Translational III | Craig M. Walsh | Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells |
$4,535,005 |
| Training Grant I-1 | Dr. Peter Bryant | Stem Cell Research Training Grant |
$1,935,487 |
| Research Training II | Dr. Peter John Donovan Dr. | UCI-CIRM Research Training Program II |
$6,067,550 |
| Early Translational II | Dr. Brian J. Cummings | Neural restricted, FAC-sorted, human neural stem cells to treat traumatic brain injury |
$1,517,767 |
| Early Translational II | Leif A Havton | Repair of Conus Medullaris/Cauda Equina Injury using Human ES Cell-Derived Motor Neurons |
$1,527,011 |
| Early Translational II | Dr. Henry John Klassen | Human retinal progenitor cells as candidate therapy for retinitis pigmentosa |
$1,803,768 |
| Early Translational II | Dr. Leslie M Thompson | A hESc-based Development Candidate for Huntington’s Disease |
$3,955,038 |
| New Faculty I | Dr. Andrew Putnam | A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells |
$395,764 |
| Early Translational I | Dr. Frank LaFerla | Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease |
$3,599,997 |
| Tools and Technologies I | Dr. Lisa A Flanagan | Novel Separation of Stem Cell Subpopulations |
$861,122 |
| Tools and Technologies I | Dr. Orhan NALCIOGLU | A MULTI-MODALITY MOLECULAR IMAGING SYSTEM (MRSPECT) FOR IN VIVO STEM CELL TRACKING |
$719,798 |
| Shared Labs | Dr. Peter J Donovan | The University of California: Irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course |
$2,107,376 |
| Shared Labs | Dr. Peter John Donovan Dr. | The University of California: Irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course |
$3,072,500 |
| New Faculty II | Dr Edwin S Monuki | Mechanisms in Choroid Plexus Epithelial Development |
$2,793,395 |
| New Cell Lines | Dr. Leslie M Thompson | New Cell Lines for Huntington’s Disease |
$1,302,526 |
| Comprehensive Grant | Dr Hans S Keirstead | hESC-Derived Motor Neurons For the Treatment of Cervical Spinal Cord Injury |
$2,158,445 |
| Comprehensive Grant | Dr. Peter John Donovan | Improved hES Cell Growth and Differentiation |
$2,381,713 |
| Comprehensive Grant | Dr. Douglas C. Wallace | The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning |
$1,790,133 |
| SEED Grant | Dr. Kyoko Yokomori | Derivation and characterization of human ES cells from FSHD embryos |
$607,200 |
| SEED Grant | Dr. Vincent Procaccio | Mitochondrial Dysfunction in Embryonic Stem Cells |
$245,397 |
| SEED Grant | Dr. Grant R MacGregor | Production of Oocytes from Human ES Cells |
$385,466 |
| SEED Grant | Thomas Edward Lane | Human Embryonic Stem Cells and Remyelination in a Viral Model of Demyelination |
$368,081 |
| SEED Grant | Dr. Frank LaFerla | Development of human ES cell lines as a model system for Alzheimer disease drug discovery |
$473,963 |
| SEED Grant | Professor Charles L Limoli | Using human embryonic stem cells to treat radiation-induced stem cell loss: Benefits vs cancer risk |
$593,242 |
| SEED Grant | Dr. Brian J. Cummings | The Immunological Niche: Effect of immunosuppressant drugs on stem cell proliferation, gene expression, and differentiation in a model of spinal cord injury. |
$595,345 |
| SEED Grant | Dr. Michelle Khine | Micro Platform for Controlled Cardiac Myocyte Differentiation |
$156,426 |
| Basic Biology II | Professor Marian L Waterman | TCF-3: A Wnt Pathway Effector and Nanog Regulator in Pluripotent Stem Cell Self-Renewal |
$1,259,879 |
| Basic Biology II | Dr. Aileen J Anderson | Role of the microenvironment in human iPS and NSC fate and tumorigenesis |
$1,256,194 |
