Functional genomics to study cellular convergence across ASD risk genes in neurodevelopment
Grant Award Details
Grant Type:
Grant Number:
DISC0-14424
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$1,575,001
Status:
Active
Grant Application Details
Application Title:
Functional genomics to study cellular convergence across ASD risk genes in neurodevelopment
Public Abstract:
Research Objective
Our objective is to enable scalable genetic screening to study how neurogenesis is impacted by risk genes implicated in human psychiatric disorders.
Impact
We will develop and apply state-of-the-art genomic analysis to seek mechanisms and disease modifying solutions.
Major Proposed Activities
Our objective is to enable scalable genetic screening to study how neurogenesis is impacted by risk genes implicated in human psychiatric disorders.
Impact
We will develop and apply state-of-the-art genomic analysis to seek mechanisms and disease modifying solutions.
Major Proposed Activities
- Identifying and validating efficient gRNA for gene editing
- Identify risk gene effects in early neurogenesis
Statement of Benefit to California:
Mental health disorders are one of the most common health conditions faced by Californian citizens: 1 in 6 California adults have experienced some form of mental illness, and 1 in 24 have a serious condition that makes it challenging to carry out major life activities. Our work is to approach the basic mechanisms involved in these disorder-implicated genetic factors to seek potential solutions to help with these devastating conditions.