Utf1: Goldilocks for ESC Bivalency.

Publication Year:

2012

Authors:

Agnieszka I Laskowski, Paul S Knoepfler

PubMed ID:

23217417

Funding Grants:

Molecular mechanisms governing hESC and iPS cell self-renewal and pluripotency

Public Summary:

Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.

Scientific Abstract:

Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.