Modeling neurological diseases using iPSC-derived neural cells : iPSC modeling of neurological diseases.
Publication Year:
2018
PubMed ID:
29079884
Funding Grants:
Public Summary:
Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of brain cells can be derived from iPSCs following developmental principles. These iPSC-derived brain cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the brain.
Scientific Abstract:
Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of neural cells, including but not limited to neural stem cells, neurons, astrocytes, oligodendrocytes and microglia, can be derived from iPSCs following developmental principles. These iPSC-derived neural cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the nervous system.