Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia.

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Grant Award Details

Grant Type:
Quest – Discovery Stage Research Projects
Grant Number:
DISC2-12169
Investigator(s):
Name:
Dr. Thomas Carmichael M.D., Ph.D.
Institution:
University of California, Los Angeles
Type:
PI

Disease Focus:
Neurological Disorders, Stroke
Human Stem Cell Use:
iPS Cell
Award Value:
$250,000
Status:
Closed

Progress Reports

Reporting Period:
Year 1

Grant Application Details

Application Title:

Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia.

Public Abstract:
Research Objective

This grant proposes development of a stem cell based therapy that is derived from human induced pluripotent stem cells. These cells are in the form of a brain support cell, an astrocyte.

Impact

The cell candidate will treat vascular dementia, the second leading cause of dementia, and stroke by overcoming a bottleneck in the ability to make large quantities of the cells for clinical use.

Major Proposed Activities

  • In vivo tumorigenic studies.
  • Development and optimization of potency assays
  • Qualification and stability of cell delivery system.
Statement of Benefit to California:
This research will develop a therapy for a disease with no treatment, vascular dementia, that is common and devastating in its consequences. The intellectual property for this therapy is held by a State of California public university (UCLA) and commercialization will directly benefit the State of California.

Publications