Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia.
Grant Award Details
Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia.
Grant Type:
Grant Number:
DISC2-12169
Project Objective:
- To complete tumorigenicity, stability and assay development studies, to declare an hIPSC candidate ready for translational stage activities.
Investigator:
Disease Focus:
Neurological Disorders
Stroke
Human Stem Cell Use:
iPS Cell
Award Value:
$250,000
Status:
Active
Grant Application Details
Application Title:
- Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia.
Public Abstract:
Research Objective
This grant proposes development of a stem cell based therapy that is derived from human induced pluripotent stem cells. These cells are in the form of a brain support cell, an astrocyte.
Impact
The cell candidate will treat vascular dementia, the second leading cause of dementia, and stroke by overcoming a bottleneck in the ability to make large quantities of the cells for clinical use.
Major Proposed Activities
- In vivo tumorigenic studies.
- Development and optimization of potency assays
- Qualification and stability of cell delivery system.
Statement of Benefit to California:
This research will develop a therapy for a disease with no treatment, vascular dementia, that is common and devastating in its consequences. The intellectual property for this therapy is held by a State of California public university (UCLA) and commercialization will directly benefit the State of California.