Development of a humanized mouse model for testing anti-HIV HSPC gene therapy strategies in HIV-1 infected mice.
Grant Award Details
Development of a humanized mouse model for testing anti-HIV HSPC gene therapy strategies in HIV-1 infected mice.
Grant Type:
Grant Number:
TRX-01431
Project Objective:
- Goal of the project is to develop a humanized mouse model for transplantation of HIV infected mice and to demonstrate disease modifying activity of gene modified CD34 encoding anti-HIV shRNA in the progeny immune cells after transplantation in this animal model.
Investigator:
Disease Focus:
HIV/AIDS
Infectious Disease
Human Stem Cell Use:
Adult Stem Cell
Award Value:
$1,505,000
Status:
Closed
Progress Reports
Reporting Period:
Year 1
View Report
Reporting Period:
Year 2 + NCE
View Report
Grant Application Details
Application Title:
- HPSC based therapy for HIV disease using RNAi to CCR5.
Public Abstract:
Statement of Benefit to California: