Grant Award Details
Developing engineered autologous leukemia vaccines to target residual leukemic stem cells
Grant Application Details
- Developing engineered autologous leukemia vaccines to target residual leukemic stem cells
A universally applicable, patient-specific leukemia vaccine engineered to express a novel immune stimulatory combination for post-remission therapy
Area of Impact
There is a critical and unmet need for new and safe treatment for older acute myelogenous leukemia (AML) patients whose current prognosis is poor
Mechanism of Action
In older patients with AML, treatment with chemotherapy can produce remission in about 50%. However, the vast majority of these individuals relapse within a year due to the persistence of residual AML and leukemia stem cells. Our engineered vaccine is designed to stimulate the patient's own immune system to generate leukemia specific immune cells that can recognize, and kill residual leukemia stem cells. Vaccination after remission could increase relapse free, and even overall survival.
Unmet Medical Need
For transplant-ineligible older AML patients, outcomes are dismal and effective immunotherapies are needed. We have shown that we can eradicate leukemia in preclinical models by treating with AML vaccines, engineered to more effectively stimulate anti-leukemic immune responses.
Submit Pre-IND package and conduct Pre-IND meeting
Major Proposed Activities
- Produce viral vector using clinical production methods and finalize steps for using virus to engineer novel patient-derived AML cell vaccines
- Finalize methods to collect, freeze, and engineer patient AML cell vaccines; Evaluate specificity of immune responses to AML versus normal bone marrow
- Generate engineered AML vaccines in a cell therapy production facility to establish and validate clinical manufacture; prepare for Pre-IND meeting
Curative AML treatment requires referral to a major medical center and toxic inpatient chemotherapy, creating financial and geographic challenges. Despite this therapy, most patients relapse. We propose a powerful strategy for converting patients' leukemia cells into effective vaccines that stimulate anti-leukemic immunity. Outpatient treatment with genetically engineered AML vaccines may be an effective strategy to decrease relapse by boosting anti-leukemic immune responses post-remission, .