Interspecies chimeras.

Return to Grants

Publication Year:

2018

Authors:

Fabian Suchy, Hiromitsu Nakauchi

PubMed ID:

29859382

Funding Grants:

Generation of functional cells and organs from iPSCs

Public Summary:

In this Review Article, we summarize recent efforts to generate human organs in animals as a way to alleviate the current shortage in donor organs.

Scientific Abstract:

By probing early embryogenesis and regeneration, interspecies chimeras provide a unique platform for discovery and clinical use. Although efficient generation of human:animal chimeric embryos remains elusive, recent advancements attempt to overcome incompatibilities in xenogeneic development and transplantation.