This is a multidisciplinary translational research project with the aim of translating latest discoveries of the role of chemokine-receptor interactions in directing stem cell migration toward injury sites in the brain and heart for regenerative repairs into novel stem cell-based regenerative medicine. We have already identified promising experiment drug candidate that will be further developed through this project into new therapeutics for the treatment of heart diseases such as stroke as well as CNS and cardiac injuries. The underlying hypothesis for this proposal is that the homing of human neural stem cells (hNSCs) to, as well as engagement and interaction with, sites of the central nervous system (CNS) injury is essential for regenerative repair process and that synthetic molecules (drugs) with activity of promoting such stem cell homing and engagement will lead to new stem cell-based therapies for CNS injuries caused by heart diseases such as stroke. Here in this application we propose to apply our technology and expertise in synthetic chemistry and stem cell biology to generate highly potent and specific small molecule agents capable of triggering and directing stem cell homing to the CNS injury sites for regenerative repairs.
Injuries in the brain and heart affect many patients in California. As the disease model studied in this particular project is representative of heart disease (stroke) and many other brain diseases, information and development candidates obtained from this project will have wide implication in studying and treating a number of brain and heart diseases. This project will lead to the translation of our technologies into new therapeutic strategies for clinically repairing injuries in the brain and heart such as those caused by stroke.