Bridges to Stem Cell Research
We are a large, urban university serving a highly diverse student population. We propose a new stem cell biology training program for master’s-level students in partnership with three leading stem cell research institutions. We propose to offer two new master’s-level specializations in our Biology department to prepare students to enter the stem cell workforce: a Masters of Science in Cell and Molecular Biology with an emphasis in Stem Cell Biology (the “MS program”) in preparation for careers as senior researchers or doctoral studies leading to faculty and research science positions in stem cell biology; and a Professional Science Masters with a concentration in Stem Cell and Regenerative Medicine (the “PSM program”) in preparation for careers as laboratory technicians and research associates. We will recruit and train 10 students each year. Both programs involve core lecture and laboratory courses in developmental, molecular, and cell biology as well as bioethics and scientific writing taught by faculty at our institution who are experts in their field. PSM students will also take business and biotechnology courses while MS students will begin the first six months of their internship in their first year. During the summer after completing their first year of the program, students will participate in a week-long intensive Stem Cell Laboratory course taught by faculty at one of the host sites where students will learn to propagate, maintain, and manipulate human embryonic stem cells. Both programs will provide students with an intensive research experience in stem cell research at one of our host institutions. MS internships will involve 18 months of original stem cell research culminating in a master’s thesis and leading to the preparation of manuscripts for publication. PSM internships will involve 12 months of research training in a stem cell research laboratory, culminating in a final written and oral research report. Mentoring and professional development are an integral part of both programs. Student cohorts will meet monthly with the Program Director (PD) to discuss their academic and research activities. Students will also gain a broader introduction to the importance and application of stem cell research from guest speakers. The PD will meet regularly with the students and their research mentors to provide continuity of programming and ensure that students thrive in their internships. Through its CIRM Bridges to Stem Cell Research program, we will offer a new general education course in Stem Cell Biology and Regenerative Medicine. This course will not only educate a broad audience, but will also provide a mechanism for recruiting students into the stem cell training programs. Thus, CIRM funding will allow our institution to make an important contribution to the stem cell workforce that truly reflects the diverse composition of our state in partnership with three preeminent research institutions.
The proposed CIRM Bridges program will benefit the state of California and its residents by providing training to prepare students to enter research careers in stem cell biology and regenerative medicine. This is particularly important and timely because our state is positioned as a result of the passage of Proposition 71 to become a leader in stem cell research both nationally and globally. With this emerging field it will be crucial to have a skilled workforce equipped to meet the scientific and technical challenges necessary for advancing scientific knowledge and alleviating human suffering. We are extremely well situated to contribute to this effort. Our Biology department has provided training for hundreds of students, those seeking to make career changes as well as those beginning their working lives. We have a long history of educating students in cutting-edge laboratory methods and responding to the needs of industry and academia. Dozens of our graduates have established careers in the sciences, and our alumni are well represented at all levels throughout the region's biotechnology industry. We have a national reputation for contributing to the diversification of the scientific profession through our many training programs which attract, recruit, and support students from groups underrepresented in the sciences, and indeed our student and our faculty are among the most ethnically and culturally diverse in the nation. With the help of our partner institutions, our CIRM Bridges program will expand the training opportunities in our Cell and Molecular Biology program to include two new specializations: stem cell biology, and biotechnology with an emphasis on regenerative medicine. We will provide a comprehensive slate of lab and lecture courses, research internships, professional mentoring, and community service opportunities to ensure that our students possess not only scientific and technical proficiency but also a thorough grasp of the ethical implications of the technology and the ability to communicate effectively with a general as well as a scientific audience. The research internships will provide training in state-of-the-art facilities in the laboratories of three premiere institutions at the forefront of stem cell research, so that students complete the program with the knowledge, skills and experience necessary to work with both federally and non-federally registered stem cell lines. We will also offer a new general education course addressing scientific, humanistic, ethical and legal perspectives on stem cell technology with special presentations open to the general public, and our students will participate in presenting their work to the broader community. Our graduates will be fully prepared to contribute to the growth of a vibrant stem cell industry that is fully reflective of the diversity of backgrounds and perspectives in our state.
Our CIRM Bridges program serves a highly diverse student population. The CIRM Bridges program funds master-level students that are in either our Masters of Science in Cell and Molecular Biology with an emphasis in Stem Cell Biology (MS program) or our Professional Science Masters with a concentration in Stem Cell and Regenerative Medicine (PSM program). Both programs involve core lecture and laboratory courses in developmental, molecular, and cell biology as well as bioethics and scientific writing taught by faculty who are experts in their field. PSM students will also take business and biotechnology courses while MS students will begin their internship in their first year of the master's program. During the summer after completing their first year of the program, 10 students will be funded with a 12-month CIRM Bridges fellowship. These CIRM fellows will participate in a week-long intensive Stem Cell Laboratory course taught by faculty at an R01 institution where students will learn to propagate, maintain, and manipulate human embryonic stem cells. During the second year of the program, when these students are funded by CIRM, they will focus all of their effort in conducting stem-cell oriented research projects at leading academic and research institutes. Throughout their time in this master's program the student receive academic and research mentorship through individual and group monthly meetings. Upon completion of the program these students are well-prepared to continue their education in PhD or health-related graduate programs as well as enter the biotechnology workforce.
Our CIRM Bridges program is situated in an urban university that serves a highly diverse student population. Our CIRM Bridges program is in partnership with three local research institutions. The CIRM Bridges program supports students in two distinct master's program that prepares students to enter the stem cell workforce: a Masters of Science in Cell and Molecular Biology with an emphasis in Stem Cell Biology (the “MS program”) and a Professional Science Masters with a concentration in Stem Cell Science (the “PSM program”). The CIRM Bridges program supports 10 students each year.
Both master's programs provide courses in developmental, molecular, and cell biology as well as bioethics and scientific writing taught by faculty. PSM students also take business and biotechnology courses. During the summer after completing their first year of the program, students participate in a week-long intensive Stem Cell Laboratory course taught by stem cell faculty at our local research medical center. CIRM Bridges students learn to propagate, maintain, and manipulate embryonic and adult stem cells.
Both programs provide students with an intensive research experience in stem cell research labs at one of our host institutions. The stem cell research training ship culminates in a draft of a manuscript and an oral thesis defense.
Mentoring and professional development are an integral part of both programs. Student cohorts meet monthly with the Program Director (PD) to discuss their academic and research activities. Students also gain a broader introduction to the importance and application of stem cell research from guest speakers. The PD meets regularly with the students and their research mentors to provide continuity of programming and ensure that students thrive in their internships.
Through its CIRM Bridges to Stem Cell Research program, we offer a new general education course "The Science and Politics of Stem Cell Research". This course educates a broad audience.
Thus, CIRM funding will allow our institution to make an important contribution to the stem cell workforce that truly reflects the diverse composition of our state in partnership with three preeminent research institutions.
The goal of San Francisco State University's CIRM Bridges Program is to prepare students for the technical and intellectual demands needed to keep California at the forefront of innovation in the development and use of stem cells to improve human health. The program at SFSU has been funded since 2009. The program is a 2-year masters in science with an emphasis in stem cell biology. The program provides graduate course work in the broad area of stem cell biology and has a strong focus on hands-on research training. The program has partnered with leading stem cell research universities and institutes including UCSF, Stanford, the Buck Institute for Research on Aging, UC Berkeley, and Children's Hospital Oakland Research Institute. We have trained over 60 students most of which have obtained excellent positions in biotech companies such as Genentech, Amgen, Novartis, Baxter Biosciences, and Gilead. They have also joined small start up companies such as StemCentrx, BioLegend, and Cellurant. Some of the graduates of our program have decided to continue with their training in PhD programs at premier institutions such as UCSF, Harvard, Stanford, and UC Davis. All of the CIRM Bridges graduates have made a significant impact in the research labs they trained in. Many have continued to work as Senior Research Associates at UCSF and Stanford to maintain the momentum of the research projects. The CIRM Bridges students have given over 80 poster presentations at local, national, and international meetings. They have also co-authored over 25 publications in the field of stem cell research in prestigious journals such as Nature and Cell Stem Cell. These are very significant achievement when considering that these students are funded for only one-year by CIRM and that this is a 2-year training program.
- Nat Med (2015) beta2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. (PubMed: 26147761)
- PLoS One (2015) Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential. (PubMed: 25723476)
- Cell Rep (2015) An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. (PubMed: 25543145)
- Cell Stem Cell (2015) The long noncoding RNA pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. (PubMed: 25800779)
- Stem Cells (2015) Role of muscle stem cells during skeletal regeneration. (PubMed: 25594525)
- Placenta (2015) The role of chorionic cytotrophoblasts in the smooth chorion fusion with parietal decidua. (PubMed: 26003500)
- Dev Biol (2015) Follicle dynamics and global organization in the intact mouse ovary. (PubMed: 25889274)
- Stem Cells Dev (2014) Inner ear hair cell-like cells from human embryonic stem cells. (PubMed: 24512547)
- Cell Rep (2014) Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules. (PubMed: 24794432)
- Endocrinology (2014) Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. (PubMed: 24684304)
- Nat Med (2014) Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. (PubMed: 24793238)
- Stem Cells Dev (2014) Genome wide profiling of dopaminergic neurons derived from human embryonic and induced pluripotent stem cells. (PubMed: 24074155)
- Endocrinology (2014) Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes. (PubMed: 25211591)
- Cell Rep (2014) Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis. (PubMed: 25176653)
- J Cardiovasc Pharmacol (2014) IL-15: a novel prosurvival signaling pathway in cardiomyocytes. (PubMed: 24805144)
- Semin Reprod Med (2013) Human trophoblast progenitors: where do they reside? (PubMed: 23329637)
- Cancer Cell (2013) A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. (PubMed: 23845442)
- Hum Mol Genet (2013) Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. (PubMed: 23077213)
- PLoS One (2013) ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. (PubMed: 23437279)
- Sci Transl Med (2012) Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. (PubMed: 22972842)
- Endocrinology (2012) Impaired placental nutrient transport in mice generated by in vitro fertilization. (PubMed: 22562173)
- PLoS One (2012) Effect of substrate stiffness on early mouse embryo development. (PubMed: 22860009)
- Brain Res Bull (2012) Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease. (PubMed: 22326483)
- Cell Rep (2012) A resource for the conditional ablation of microRNAs in the mouse. (PubMed: 22570807)
- Addict Biol (2012) Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. (PubMed: 22339852)