Grant Award Details
To further characterize the functionality and variability ofiPSC-derived dopaminergic neurons derived from Parkinson’s patients for thedevelopment of an autologous, cell-based therapy.
Grant Application Details
- Autologous cell therapy for Parkinson’s disease using iPSC-derived DA neurons
Autologous human dopaminergic neurons derived from patient-specific induced pluripotent stem cells
Major Proposed Activities
- Characterize differentiation from all 10 patient cell lines
- Characterize functionality of patient neurons matured in vitro
- Immunogenicity assessment
- Cryopreservation feasibility testing
- Investigate dose response in vivo
- Detect dopamine release in vivo
Thousands of Californians suffer from the degenerative effects of Parkinson's disease, a disease for which there is no cure. There is hope, however, that stem cells could provide the key to providing long-term relief. Our study seeks to treat patients with cells derived from their own stem cells, a process which could be applied to other diseases such as diabetes and heart disease and could potentially be used to the benefit of many of the citizens of California.