Reprogramming of human primary somatic cells by OCT4 and chemical compounds.

Cell Stem Cell
Publication Year: 
Saiyong Zhu
Wenlin Li
Hongyan Zhou
Wanguo Wei
Rajesh Ambasudhan
Tongxiang Lin
Janghwan Kim
Kang Zhang
Sheng Ding
PubMed link: 
Public Summary: 
In this study we report a small molecule cocktail that enables reprogramming of human primary somatic cells to iPSCs with exogenous expression of only OCT4. In addition, mechanistic studies revealed that modulation of cell metabolism from mitochondrial oxidation to glycolysis plays an important role in reprogramming.
Scientific Abstract: