A new notch for lung stem cells.

Journal: 
Cell Stem Cell
Publication Year: 
2015
Authors: 
Gianni Carraro
Barry R Stripp
PubMed link: 
25658364
Public Summary: 
Homeostasis and repair of different lung compartments require the selective activation of specific progenitor/stem cells and their regulated differentiation to yield cell types that fulfill specialized regional functions. We discuss recent literature that sheds light on pathways that pre-determine the fate of lung epithelial progenitor cells.
Scientific Abstract: 
Homeostasis and repair of different lung compartments require the selective activation of specific progenitor/stem cells and their regulated differentiation to yield cell types that fulfill specialized regional functions. In this issue of Cell Stem Cell, Pardo-Saganta et al. (2015) identify Notch signaling as a determinant of basal cell heterogeneity and fate decisions in pseudostratified airways.