Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells.

Journal: 
Adv Healthc Mater
Publication Year: 
2013
Authors: 
Andreina Parisi-Amon
Widya Mulyasasmita
Cindy Chung
Sarah C Heilshorn
PubMed link: 
23184882
Public Summary: 
Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology.
Scientific Abstract: 
Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology.