Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

Journal: 
Chem Commun (Camb)
Publication Year: 
2013
Authors: 
Matthew A Inlay
Veronica Choe
Sophia Bharathi
Nathaniel B Fernhoff
James R Baker
Irving L Weissman
Seok Ki Choi
PubMed link: 
23612712
Public Summary: 
Scientific Abstract: 
We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.