Interspecies chimeras.

Curr Opin Genet Dev
Publication Year: 
Fabian Suchy
Hiromitsu Nakauchi
PubMed link: 
Public Summary: 
In this Review Article, we summarize recent efforts to generate human organs in animals as a way to alleviate the current shortage in donor organs.
Scientific Abstract: 
By probing early embryogenesis and regeneration, interspecies chimeras provide a unique platform for discovery and clinical use. Although efficient generation of human:animal chimeric embryos remains elusive, recent advancements attempt to overcome incompatibilities in xenogeneic development and transplantation.