iPSC-Derived Organs In Vivo: Challenges and Promise.
Cell Stem Cell
In this paper, we discuss the clinical potential of generating solid organs from iPSCs using interspecies organogenesis. We describe the challenges and potential solutions in moving this basic research into a clinical treatment for patients.
Transplanting iPSCs into the embryos of another species can generate functional organs for basic research and translational applications. We discuss forward-looking approaches and address key remaining challenges of generating iPSC-derived human organs in vivo.