Neural progenitor cells regulate microglia functions and activity.

Nat Neurosci
Publication Year: 
Kira I Mosher
Robert H Andres
Takeshi Fukuhara
Gregor Bieri
Maiko Hasegawa-Moriyama
Yingbo He
Raphael Guzman
Tony Wyss-Coray
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Public Summary: 
Scientific Abstract: 
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.