by Amy Adams on December 4, 2008 at 11:51AM | comments
Researchers at UC, Los Angeles have found that blood-forming stem cells in mice have their origins in the endothelial cells that line blood vessels during mid-gestation. These cells eventually move to the bone marrow where they generate all the cells of the blood system throughout life. Researchers have long known that blood-forming stem cells arise from the blood vessels, but didn't know exactly which cell type acted as the source. Now that the source is know, the researchers want to learn what signals those endothelial cells to begin producing blood-forming stem cells.