Summaries of review for applications to RFA 10-04 Basic Biology III

Review Summaries for RFA 10-04: CIRM Basic Biology III Awards

The following is a listing of all applications reviewed under RFA 10-04 for CIRM Basic Biology III Awards. Applications include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Grants Working Group (GWG). A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.

 
= Recommended for funding  
 
= Not Recommended for funding at this time
Application Number Approval Title Scientific Score
RB3-05100 Approved Enhancer-mediated gene regulation during early human embryonic development 90
RB3-05129 Approved Elucidating Molecular Basis of Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells 89
RB3-05103 Approved Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC 83
RB3-05009 Approved Neural and general splicing factors control self-renewal, neural survival and differentiation 83
RB3-02161 Approved Use of human iPS cells to study spinal muscular atrophy 82
RB3-05083 Approved Functional characterization of mutational load in nuclear reprogramming and differentiation 82
RB3-02143 Approved Generation and characterization of corticospinal neurons from human embryonic stem cells 79
RB3-05022 Approved Triplet Repeat Instability in Human iPSCs 79
RB3-02222 Approved Ubiquitin-dependent control of hESC self-renewal and expansion 79
RB3-05080 Approved Discovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells 76
RB3-02266 Approved Biological relevance of microRNAs in hESC differentiation to endocrine pancreas 75
RB3-02165 Approved Etsrp/ER71 mediated stem cell differentiation into vascular lineage 73
RB3-05066 Approved USP16 controls stem cell number: implications for Down Syndrome 73
RB3-02186 Approved Identifying sources of mutation in human induced pluripotent stem cells by whole genome sequencing 73
RB3-05217 Approved Forming the Hematopoietic Niche from Human Pluripotent Stem Cells 72
RB3-05041 Approved Phenotypic Analysis of Human ES Cell-Derived Muscle Stem Cells 72
RB3-05020 Approved Genomic instability during culturing of human embryonic stem cells 71
RB3-05219 Approved Viral-host interactions affecting neural differentiation of human progenitors 71
RB3-02098 Approved Molecular basis of human ES cell neurovascular differentiation and co-patterning 70
RB3-05232 Approved Induced Pluripotent Stem Cells for Tissue Regeneration 70
RB3-05229 Approved Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells 69
RB3-05086 Approved Characterization and Engineering of the Cardiac Stem Cell Niche 69
RB3-02209 Approved Correlated time-lapse imaging and single cell molecular analysis of human embryo development 68
RB3-05174 Approved Mechanisms of Direct Cardiac Reprogramming 67
RB3-02221 Approved Understanding the role of LRRK2 in iPSC cell models of Parkinson's Disease 65
RB3-05095   Enhancing Maturation of hESC Derived hepatocytes Using Decellularized Liver Matrix -
RB3-05197   Contribution of MeCP2 to reprogramming and synaptogenesis -
RB3-05092   Analysis of CTCF-dependent genome organization in pluripotent hESCs and hiPSCs -
RB3-05106   Mechanisms of Cardiomyocyte Maturation -
RB3-02087   WNT signaling in neural stem cell self renewal and neural crest cell specification and migration -
RB3-05016   Biophysical Reprogramming of Pluripotency -
RB3-05236   Aneuploidies in pluripotent stem cells and their effects on tumorigenicity & tissue differentiation -
RB3-02244   Forkhead Factors in hESC Growth and Self-renewal -
RB3-05186   Modeling and correction of genetic skeletal dysplasias in iPSCs -
RB3-05138   Generating fully functional human hematopoietic stem cells in vitro from pluripotent cells -
RB3-05050   Molecular Regulation of Human Pluripotent Stem Cell Functions -
RB3-05171   Exploiting natural mechanisms to derive human cardiomyocytes for modeling disease and regeneration -
RB3-05088   The link between mitochondrial dynamics and metabolism in hESC and hiPSC differentiation -
RB3-02267   Molecular characterization of multipotent hemangioblasts from hES/hiPS cells in defined conditions -
RB3-05087   Making Stem Cell Therapies Safer: Targeting ES Cells with Cell Cycle and miRNA Antagonists -
RB3-05207 Approved Molecular determinants of accurate differentiation from human pluripotent stem cells --
RB3-05001   Mechanisms of regeneration of the large airways -
RB3-02129 Approved Studying neurotransmission of normal and diseased human ES cell-derived neurons in vivo --
RB3-05250   Elucidating molecular basis of ICF Syndrome with human pluripotent stem cells -
RB3-02236   Molecular control of the bidirectional transition between stem cells and skeletal muscles -
RB3-02119   Molecular Determinants Controlling Dopaminergic Lineage In Human Neural Stem Cells -
RB3-02293   Stem Cell-Derived Replacement Tissue for Diabetes Therapy -
RB3-05134   Mechanobiology of aged stem cells: A foundation for improved musculoskeletal healing in the elderly -
RB3-05039   Mechanisms of death and survival of transplanted oligodendrocyte progenitor cells -
RB3-05254   In vivo synaptic function in human neurogenetic disease -
RB3-02101   Muscle Stem Cell Renewal in a Bioengineered Regenerative Niche -
RB3-02260   Regulation of Alternative Splicing During Embryonic Stem Cell Differentiation -
RB3-02177   Single Cell Analysis of Retrotransposition and Genetic Mosaicism during Stem Cell-based Neurogenesis -
RB3-02157   Development and Evaluation of Stem Cell based Therapy for Diffuse Parenchymal Lung Diseases -
RB3-05127   Dissecting the molecular basis of mesoderm formation -
RB3-02213   Defining the epigenetic blockage that limits in vitro human oligodentrocyte terminal differentiation -
RB3-02149   Role of Metabolism in Human Embryonic Stem Cells -
RB3-05115   Mechanism of selective induction of apoptosis in leukemic stem cells by antibodies to EphA3 -
RB3-05239   Probing Histone Deacetylase 7 in Cystic Fibrosis iPSCs -
RB3-05025   Human iPSC Genome Stabilization During the Gene Correction Process -
RB3-05109   Functional Genomics of Cardiopoiesis -
RB3-02214   Mechanisms Controlling Lineage and Synaptic Specificity of Human Neurons During Transdifferentiation -
RB3-05029   Transcriptional and Epigenetic Variability in hESC Derived Retinal Pigmented Epithelial Cells -