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Summaries of Review for Applications to RFA 06-02
The following is a listing of all applications reviewed under RFA 06-02 for CIRM Comprehensive Grants. Applications are ordered by application number and include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Scientific and Medical Research Funding Working Group (SMRFWG) during the review meeting on January 8-10, 2007. A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.
= Recommended for funding = Recommended if funds available = Not Recommended at this time
| Application Number | Title | Scientific Score |
|---|---|---|
| RC1-00100-1 | Functional Genomic Analysis of Chemically Defined Human Embryonic Stem Cells | 84 |
| RC1-00101-1 | IN VIVO REGENERATIVE POTENTIAL OF hESC-DERIVED SKELETAL MYOBLASTS | |
| RC1-00102-1 | Generation and functional genomic characterization of human embryonic stem cell-derived progenitor cells. | 64 |
| RC1-00103-1 | Factors Regulating Stemness in Human Embryonic Stem Cells | |
| RC1-00104-1 | Modeling Myocardial Therapy with Human Embryonic Stem Cells | 83 |
| RC1-00105-1 | Creating a Human Tumor Micro-environment with Embryonic Stem Cells | |
| RC1-00106-1 | Generating Reprogrammed Pluripotent Human Cell Lines Using a Histone Modification Barcode | |
| RC1-00107-1 | Controlling Stem Cell Differentiation with GPCR Signals | 69 |
| RC1-00108-1 | Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC) | 69 |
| RC1-00109-1 | Chemical and Functional Genomic Approaches toward Understanding hESCs | |
| RC1-00110-1 | Improved hES Cell Growth and Differentiation | 85 |
| RC1-00111-1 | Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair | 95 |
| RC1-00112-1 | Intracellular signaling mechanism for control of hESC pluripotency | |
| RC1-00113-1 | Constructing a fate map of the human embryo | 88 |
| RC1-00114-1 | hES Differentiation in Lesch Nyhan Disease | 64 |
| RC1-00115-1 | Molecular and Cellular Transitions from ES Cells to Mature Functioning Human Neurons | 89 |
| RC1-00116-1 | USING HUMAN EMBRYONIC STEM CELLS TO UNDERSTAND AND TO DEVELOP NEW THERAPIES FOR ALZHEIMER'S DISEASE | 85 |
| RC1-00117-1 | Interaction between transplanted human embryonic stem cell-derived neuronal precursors and endogenous neurogenesis in ischemic brain | |
| RC1-00119-1 | Generation of inner ear sensory cells from human ES cells toward a cure for deafness | 84 |
| RC1-00120-1 | Genome-wide analysis of hormonal systems important for human embryonic stem cell derivation | |
| RC1-00121-1 | Human Embryonic Stem Cell Therapy for Myocardial Infarction | |
| RC1-00122-1 | Genetic Modification of Human Embryonic Stem Cells | |
| RC1-00123-1 | Establishment Of Stem Cell Lines From Somatic Cell Nuclear Transfer-Embryos in Humans | 77 |
| RC1-00124-1 | Embryonic Stem Cell-Derived Therapies Targeting Cardiac Ischemic Disease | 79 |
| RC1-00125-1 | MEF2C-Directed Neurogenesis From Human Embryonic Stem Cells | 78 |
| RC1-00126-1 | Constructing a library of custom-tailored human embryonic stem cell-derived cardiomyocytes for specific heart therapies | |
| RC1-00127-1 | Effect of growth factors on hES cell derivation, growth, and genomic stability | |
| RC1-00128-1 | Control of human Embryonic Stem Cell Pluripotence and Fate Choice | |
| RC1-00129-1 | Mechanisms of Human Embryonic Stem Cell Self-Renewal | |
| RC1-00130-1 | Monitored Systemic Delivery Of HESC to Pathological Organs | |
| RC1-00131-1 | Spinal ischemic paraplegia: modulation by human embryonic stem cell implant. | 83 |
| RC1-00132-1 | Chemical Genetic Approach to Production of hESC-derived Cardiomyocytes | 85 |
| RC1-00133-1 | Guiding the developmental program of human embryonic stem cells by isolated Wnt factors | 75 |
| RC1-00134-1 | Immunology of neural stem cell fate and function | 79 |
| RC1-00135-1 | Human stem cell derived oligodendrocytes for treatment of stroke and MS | 75 |
| RC1-00136-1 | Human Embryonic Stem Cell Survival and Transformation | |
| RC1-00137-1 | Human oocyte development for genetic, pharmacological and reprogramming applications | 79 |
| RC1-00138-1 | Studying Chromosomal Aneuploidy During Human Embryogenesis Using Human Embryonic Stem Cells Derived From Embryos Characterized by Preimplantation Genetic Diagnosis | |
| RC1-00139-1 | Investigation of the mechanism that initiates the molecular heterogeneity in human embryonic stem cells | |
| RC1-00140-1 | Derivation and Characterization of hESCs Derived from Single Cleavage-Stage Blastomeres | |
| RC1-00141-1 | Functional characterization of the pivotal role of a novel zinc finger protein ZNF206 in regulating early lineage allocation & commitment | |
| RC1-00142-1 | microRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells | 72 |
| RC1-00144-1 | Preclinical Model for Labeling, Transplant, and In Vivo Imaging of Differentiated Human Embryonic Stem Cells | 66 |
| RC1-00145-1 | Control Mechanisms Governing Human ESC Self Renewal and Differentiation | 65 |
| RC1-00146-1 | Endoderm-specific integration for human embryonic stem cells: towards tissue regenerative solutions for lung and pancreas | |
| RC1-00147-1 | DESIGN AND ENGINEERING OF NEURAL STEM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS FOR REGENERATION AND REPAIR OF MULTIPLE SCLEROSIS | |
| RC1-00148-1 | Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells | 81 |
| RC1-00149-1 | Human Embryonic Stem Cell Therapeutic Strategies to Target HIV Disease | 73 |
| RC1-00151-1 | Engineering a Cardiovascular Tissue Graft from Human Embryonic Stem Cells | 75 |
| RC1-00152-1 | Dopaminergic Differentiation of Human Embryonic Stem Cells | 64 |
| RC1-00337-1 | Generation of hNSC lines from hESC: Effect of selective derivation and transplantation niche on cell fate decisions and recovery after SCI | |
| RC1-00338-1 | Converting Human Embryonic Stem Cells to Dopamine Neurons for Parkinson's Disease | |
| RC1-00339-1 | Human Embryonic Stem Cells for Incurable Skin Diseases and Chronic Wounds | |
| RC1-00340-1 | Engineering human embryonic stem cells into ectodermal organs | |
| RC1-00341-1 | Building an HIV Resistant Immune System Using Pluripotent Stem Cells | |
| RC1-00343-1 | Quantitative time-lapse analysis of pluripotency and trophectoderm differentiation at the single-cell level | |
| RC1-00344-1 | Matrix-Assisted hESC Transplantation for Myocardium Stabilization | |
| RC1-00345-1 | hESC-Derived Motor Neurons For the Treatment of Cervical Spinal Cord Injury | 66 |
| RC1-00346-1 | Derivation of Inhibitory Nerve Cells from Human Embryonic Stem Cells | 90 |
| RC1-00347-1 | Understanding hESC-based Hematopoiesis for Therapeutic Benefit | 79 |
| RC1-00349-1 | Embryonic Stem Cell-Derived Hemangioblasts for Hematopoietic Stem Cell Reconstitution | |
| RC1-00350-1 | Human Embryonic Stem Cell for Myocardial Restoration | |
| RC1-00351-1 | Cryopreservation of Embryonic Progenitors Derived from Human Embryonic Stem Cells | |
| RC1-00353-1 | The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning | 87 |
| RC1-00354-1 | Prospective isolation of hESC-derived hematopoietic and cardiomyocyte stem cells | 89 |
| RC1-00356-1 | ABILITY OF HUMAN ES CELL-DERIVED NEURAL PRECURSORS TO CONTRIBUTE TO AND REPAIR DAMAGED NEURAL CIRCUITS | 68 |
| RC1-00358-1 | Embryonic stem cell-derived neural stem cells for brain tumor and ALS therapy. | |
| RC1-00359-1 | An in vitro and in vivo comparison among three different human hepatic stem cell populations. | 87 |
| RC1-00459-1 | Imaging Human ES-Derived Cells: Defining Parameters for Safety in Regenerative Medicine. | |
| RC1-00478-1 | Regulation of Self Renewal and Lineage Commitment in Human Embryonic Stem Cells |