California Institute for regenerative medicine
The State stem cell agency

iPS cells: insights into basic biology.

Journal: 
Cell
Publication Year: 
2009
Authors: 
Miguel Ramalho-Santos
PubMed link: 
Read the abstract
Funding Grants: 
Somatic cell age and memory in the generation of iPS cells
Transcriptional Regulation of Human Embryonic Stem Cells
Public Summary: 
This a review article where I propose that the process of iPS cell generation may provide important novel insights into basic biological processes, such regulation of gene activity during embryonic development or cellular transformation in cancer.
Scientific Abstract: 
The discovery that adult somatic cells can be induced to become pluripotent by overexpression of a few key transcription factors provides an exciting new window into the basic biology of pluripotency and differentiation.