The J. David Gladstone Institutes

Award Value
Early Translational IV: Steven Finkbeiner Recruiting stem cells for blood vessel regeneration $2,278,080
Shared Labs: Sheng Ding The Cedars-Sinai International Stem Cell Research Institute Shared Laboratory Facilities $1,440,164
New Faculty II: Yadong Huang Isolation of a homogeneous population of hESC-derived ventricular cardiomyocytes $2,843,770
New Faculty II: Yadong Huang Human Limbal Epithelial Stem Cell Conversion into Photoreceptors for Treatment of Retinal Degeneration $2,843,770
New Cell Lines: Robert Farese Large-Scale Reprogramming of Human Somatic Cells to a Pluripotent Stem Cell-Like State $1,696,424
New Cell Lines: Robert Farese Comparison of New Lines from Multiple Sources $1,696,424
New Cell Lines: Bruce Conklin Generation and Testing of Induced Pluripotent Stem Cell Lines for Understanding Human Oligodendrocyte Development and Disease $1,708,560
New Cell Lines: Bruce Conklin Isolation and Characterization of A Novel Stem Cell Line from Amniotic Fluid and their Potential for Regenerative Medicine Applications $1,708,560
SEED Grant: Fen-Biao Gao Alternative splicing during neural differentiation of human embryonic stem cells. $748,800
SEED Grant: Warner Greene EFFECTS OF SMALL MOLECULE LIBRARIES ON DIFFERENTIATION OF EMBRYONIC AND NERAL STEMS CELLS IN DOPAMINERGIC PHENOTYPE $717,363
SEED Grant: Warner Greene Generation of Inherited Disease Human Embryonic Stem Cell Lines $717,363
SEED Grant: Warner Greene Targeting lentiviral vectors to modified hES derived dendritic cells $717,363
SEED Grant: Warner Greene The Use of Microfluidic Chambers and Microtechnology to Study hESC-derived Neural Cells $717,363
Shared Labs: Deepak Srivastava RSI Stem Cell Biology Open Research Center $842,672
Early Translational I: Warner Greene Identification of cancer stem cell-specific internalizing scFvs for pre-clinical antibody-drug conjugate development $1,324,011
Early Translational IV: Steven Finkbeiner Selective small molecule inhibitors of glioblastoma cancer stem cells $2,278,080
Basic Biology IV: Sheng Ding Mechanisms to generate functional replacement β-cells from multipotent human stem cells $1,708,560
Basic Biology IV: Steven Finkbeiner Exploring the role of WNT signaling in neural progenitor cells $1,506,420
Basic Biology IV: Steven Finkbeiner Identification and validation of biomarkers in autism using adult stem cells and iPS cells $1,506,420
Basic Biology IV: Steven Finkbeiner Protein Homeostasis as a Critical Mediator of Stem Cell Function $1,506,420
Early Translational III: Deepak Srivastava Transplantation of stem-cell-derived retinal progenitor and RPE sheets to restore vision $6,319,110
Early Translational III: Deepak Srivastava Allogeneic hESC-Derived Neural Stem Cells in Acute Neonatal Hypoxic-Ischemic Brain Injury $6,319,110
Basic Biology III: Deepak Srivastava Mechanisms of death and survival of transplanted oligodendrocyte progenitor cells $1,708,560
Basic Biology III: Deepak Srivastava Development and Evaluation of Stem Cell based Therapy for Diffuse Parenchymal Lung Diseases $1,708,560
Early Translational I: Warner Greene Selection, maturation induction and enrichment of pacemaker cells from stem cells for generating biological pacemakers in clinical therapy $1,324,011
Early Translational I: Warner Greene Prevention and Treatment of Teratoma Formation During Stem Cell Therapy $1,324,011
Early Translational I: Warner Greene Treatment of Sickle Cell Anemia and Thalassemia $1,324,011
SEED Grant: Eric Verdin MOLECULAR MECHANISMS OF CELL MOTILITY IN HUMAN NEURAL STEM CELLS $590,997
New Cell Lines: Bruce Conklin Induced Pluripotent Stem Cells for Cardiovascular Diagnostics $1,708,560
Training Grant I-2: Robert Mahley Gladstone CIRM Scholar Program $2,192,073
Research Training II: Robert Mahley Gladstone CIRM Scholars Program $5,111,046
Basic Biology III: Deepak Srivastava Mechanisms of Direct Cardiac Reprogramming $1,708,560
New Faculty I: Sheng Ding Reprogramming of human somatic cells back to pluripotent embryonic stem cells $1,414,664
Shared Labs: Deepak Srivastava The Gladstone CIRM Shared Human Embryonic Stem Cell Core Laboratory $1,698,515
Early Translational I: Warner Greene Maximizing the Safety of Induced Pluripotent Stem Cells as an Infusion Therapy: Limiting the Mutagenic Threat of Retroelement Retrotransposition during iPSC Generation, Expansion and Differentiation $1,324,011
Comprehensive Grant: Deepak Srivastava microRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells $2,994,719
New Faculty II: Yadong Huang Defining the Isoform-Specific Effects of Apolipoprotein E on the Development of iPS Cells into Functional Neurons in Vitro and in Vivo $2,843,770
New Faculty II: Benoit Bruneau Induction of cardiogenesis in pluripotent cells via chromatin remodeling factors $2,815,309
SEED Grant: Warner Greene The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells $717,363
SEED Grant: Fen-Biao Gao MicroRNAs in Human Stem Cell Differentiation and Mental Disorders $748,800
SEED Grant: Eric Verdin Role of HDAC in human stem cells pluripotentiality and differentiation $590,997
New Cell Lines: Sheng Ding Derivation of New ICM-stage hESCs $778,859
New Cell Lines: Robert Farese Establishment of Frontotemporal Dementia Patient-Specific Induced Pluripotent Stem (iPS) Cell Lines with Defined Genetic Mutations $1,696,424
Early Translational III: Deepak Srivastava Direct Cardiac Reprogramming for Heart Regeneration $6,319,110
Basic Biology IV: Steven Finkbeiner Common molecular mechanisms in neurodegenerative diseases using patient based iPSC neurons $1,506,420
Basic Biology IV: Benoit Bruneau Epigenetic regulation of human cardiac differentiation $1,708,560
Research Leadership 14: Todd McDevitt Engineering microscale tissue constructs from human pluripotent stem cells $6,368,285
Shared Labs: Deepak Srivastava The Gladstone CIRM Shared Human Embryonic Stem Cell Core Laboratory $842,672
Shared Labs: Sheng Ding TSRI Center for hESC Research $1,440,164
Disease Team Planning: Deepak Srivastava Pluripotent Stem Cell–Based Therapy for Heart Disease $13,505
Basic Biology V: Sheng Ding A novel druggable mechanism to safeguard stem cell genome $1,423,800
Research Leadership 12: Kevin Parker Engineering Cardiac Tissue for Regeneration and Drug Development $0
Early Translational IV: Steven Finkbeiner Development of Novel Autophagy Inducers to Block the Progression of and Treat Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Diseases $2,278,080
Creativity Awards: Shannon Noonan Gladstone Summer Scholars (GSS) internship program $27,674
Basic Biology IV: Sheng Ding A new paradigm of lineage-specific reprogramming $1,708,560
SEED Grant: Warner Greene EFFECTS OF SMALL MOLECULE LIBRARIES ON DIFFERENTIATION OF EMBRYONIC AND NERAL STEMS CELLS IN DOPAMINERGIC PHENOTYPE $717,363
SEED Grant: Warner Greene Generation of Inherited Disease Human Embryonic Stem Cell Lines $717,363
SEED Grant: Warner Greene The Use of Microfluidic Chambers and Microtechnology to Study hESC-derived Neural Cells $717,363
SEED Grant: Eric Verdin MOLECULAR MECHANISMS OF CELL MOTILITY IN HUMAN NEURAL STEM CELLS $590,997
SEED Grant: Fen-Biao Gao Alternative splicing during neural differentiation of human embryonic stem cells. $748,800
SEED Grant: Warner Greene Targeting lentiviral vectors to modified hES derived dendritic cells $717,363
Total:
$107,314,706.00
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