University of California, Los Angeles
ICOC Committed funds:
Awards as PI
Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells.
X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations.
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.