Stroke (cerebral ischemia) is the third leading cause of death in the USA. Currently, there are no effective treatments once a stroke has occurred and damage to the brain is complete. In this proposal we aim to develop human embryonic stem cells for both diagnostic and therapeutic purposes to treat stroke. We hope to develop new drug treatments as well as cell-based therapies using transplanted cells derived from embryonic stem cells that become new brain cells to replace those lost during a stroke. A wide range of California experts, including physicians, professors, and biotech researchers, will participate in the development and planning aspects of these new treatments.
Statement of Benefit to California:
Stroke (cerebral ischemia) is the third leading cause of death in the USA. Currently, there are no effective treatments once a stroke has occurred and brain damage is completed. Here we propose to develop new treatments for stroke using human embryonic stem cells. These new treatments will benefit California and its citizens in several ways. It will improve the health of Californians suffering from stroke by reducing mortality. It will create new jobs to develop these therapies and thus help the economy. Finally, it is anticipated that these new cell-based therapies for stroke will lead to a better quality of life for the citizens of California since stroke not only leads to death but also severe disabilities in those affected.