Procurement of tissue samples for the generation of induced pluripotent stem cells from patients afflicted with cardiovascular diseases and diabetes.

Funding Type: 
Tissue Collection for Disease Modeling
Grant Number: 
IT1-06616
Investigator: 
ICOC Funds Committed: 
$0
Public Abstract: 
Cardiovascular disease (CVD) is a complex disease with strong genetic components. It remains the leading cause of death worldwide representing 30% of all global deaths. Atherosclerosis is a common CVD that manifests in plaque formation in the vascular wall of the arteries. Progression of the disease can result in occlusion of the vessel and ischemia. Similarly, 6.4% of adults on the planet have diabetes. In the United States, 8.3% of people have diabetes and nearly 3% of all deaths are due to diabetes. In California, 7.6% of people have diabetes. The incidence of CVD in diabetic patients is 2-14 times higher than in age matched, non-diabetic patients. iPSCs hold a great deal of promise in both the fields of regenerative medicine and disease therapy. By using disease state somatic cells for iPSC generation, the iPSCs retain the genetic mutations that resulted in the disease state. The disease state iPSCs can then be differentiated into any number of different cell types to study everything from disease onset and progression to the impact of specific therapies on the afflicted cell types. All of these experiments can be performed in vitro allowing for the reduction of the number of animals needed while streamlining the progression of therapies from bench top to bedside. The overall plan of this research project is to obtain a large number of atherosclerotic and diabetic blood and tissue samples. These can then be used for iPSC generation to accelerate translational medicine.
Statement of Benefit to California: 
Cardiovascular disease (CVD) is a complex disease with strong genetic components. It remains the leading cause of death worldwide representing 30% of all global deaths. Atherosclerosis is a common CVD that manifests in plaque formation in the vascular wall of the arteries. Progression of the disease can result in occlusion of the vessel and ischemia. Similarly, 6.4% of adults on the planet have diabetes. In the United States, 8.3% of people have diabetes and nearly 3% of all deaths are due to diabetes. In California, 7.6% of people have diabetes. The incidence of CVD in diabetic patients is 2-14 times higher than in age matched, non-diabetic patients. iPSCs hold a great deal of promise in both the fields of regenerative medicine and disease therapy. By using disease state somatic cells for iPSC generation, the iPSCs retain the genetic mutations that resulted in the disease state. The disease state iPSCs can then be differentiated into any number of different cell types to study everything from disease onset and progression to the impact of specific therapies on the afflicted cell types. All of these experiments can be performed in vitro allowing for the reduction of the number of animals needed while streamlining the progression of therapies from bench top to bedside. The overall plan of this research project is to obtain a large number of atherosclerotic and diabetic blood and tissue samples. These can then be used for iPSC generation to accelerate translational medicine.

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