Epicardial progenitor cells in cardiac regeneration.

Funding Type: 
New Faculty II
Grant Number: 
RN2-00936
Investigator: 
ICOC Funds Committed: 
$0
oldStatus: 
Closed
Public Abstract: 
Coronary artery disease, which often results in congestive heart failure, cannot be cured with conventional treatments, suggesting the need of alternate and novel methodologies to confront this disease and its associated pathologies. In the current context, stem cell-based therapy points to one of the most promising alternatives for the cure of coronary disease. Our main focus of the research is the analysis of the mechanisms that regulate the formation of the coronary vasculature from precursor cells in the epicardium, which is the outermost layer of the heart near where the coronary vessels develop. We have gathered data that indicates that human embryonic stem cells can be used as a source of epicardial progenitors for coronary vessel repair and cardiac regeneration. This proposal aims to lay groundwork for coronary vascular therapy and cardiac repair based on embryonic stem cell technology.
Statement of Benefit to California: 
Heart disease is a leading cause of mortality in California. In particular, coronary artery disease, which often results in congestive heart failure, cannot be cured with conventional treatments, suggesting the need of alternate and novel methodologies to confront this disease and its associated pathologies. In the current context, stem cell-based therapy points to one of the most promising alternatives for the cure of coronary disease.

© 2013 California Institute for Regenerative Medicine