Grant Award Details

Directed Differentiation of Specialized Endothelial Cells
Grant Type: 
Grant Number: 
RB5-07414
Project Objective: 
  • The overall goal of the project is to understand endothelial cell (EC) differentiation to provide a basis for the in vitro derivation of distinct EC subtypes.
Investigator: 
Type: 
PI
Disease Focus: 
Vascular Disease
Human Stem Cell Use: 
Embryonic Stem Cell
iPS Cell
Award Value: 
$475,686
Status: 
Closed

Progress Reports

Reporting Period: 
Year 1
Reporting Period: 
Year 2

Grant Application Details

Application Title: 
  • Directed Differentiation of Specialized Endothelial Cells
Public Abstract: 

Vascular endothelial cells (EC) or endothelial progenitor cells (EPC) derived from stem cells could potentially lead to a variety of clinically relevant therapeutic applications, including various strategies for treating heart and vascular diseases. However, because EC exhibit a variety of functionally distinct subphenotypes, it is important to be able to generate the appropriate endothelial type. This study will explore the limits and importance of EC fate and generate methodologies for directing EC subphenotypes.

Statement of Benefit to California: 

Vascular endothelial cells (EC) or endothelial progenitor cells (EPC) derived from stem cells could potentially lead to a variety of clinically relevant therapeutic applications, including various strategies for treating heart and vascular diseases. However, because EC exhibit a variety of functionally distinct subphenotypes, it is important to be able to generate the appropriate endothelial type. This study will explore the limits and importance of EC fate and generate methodologies for directing EC subphenotypes for treating these patients.