We propose a multi-institutional, multi-disciplinary Type III CIRM Training Program to train Post-doctoral Fellows. It is anticipated that there will be 6 Post-doctoral Fellows trained per year for a period of 2 years, with the option to renew for an additional year. The CIRM sponsored training program will include both didactic courses and laboratory courses as well as seminar and literature-based lectures/discussion that will encompass the strengths of researchers and clinicians at our institute and our collaborators at affiliated institutions in [REDACTED]. The didactic courses will cover 2 subject areas: 1) Embryonic and Adult Stem Cell Biology and 2) Ethical, Social, Legal, and Political Implication of Stem Cell Research. The laboratory courses will feature numerous technologies relevant to stem cell research that will be embodied in 2 courses: 1) Generation and Culture of Pluripotent and Multipotent Stem Cells and 2) Generation of Transgenic Stem Cells. In addition, there are seven Topics (Neurobiology: Development and Disease; Cardiology: Development and Disease; Genetic, Cellular, and Clinical Basis of Disease; Epidemiological Basis for Therapeutic Development; Adult and Hematopoietic Stem Cell Biology; Scientific Entrepreneurism; Molecular Genetics of Embryonic Stem Cells that will be covered in a seminar/literature-based course that will be supplement the didactic and lab courses that will comprise a Stem Cell Seminar Series, a Stem Cell Journal Club, and a yearly Stem Cell Meeting. The trainees will have research opportunities in the areas of embryonic and adult stem cell growth and differentiation, genetic diseases, cell and gene therapy, cancer biology, cardiac biochemistry, neurobiology and neurodegenerative diseases. Scientists and clinicians from our institute and affiliated institutions are committed to contribute their expertise to train postdoctoral fellows in stem cell biology, ethics, and practical laboratory skills as well as provide them with manuscript and grant writing opportunities that will prepare them for careers in academic medicine and/or biotechnology.
Statement of Benefit to California:
We propose a multi-institutional, multidisciplinary Type III CIRM Training Program to train Post-doctoral Fellows in regenerative medicine and human embryonic stem cell biology. Regenerative medicine represents the effort of cell biologists to invent a new approach to the problem of degenerative disease. Human embryonic stem (hES) cells have the potential to become all of the cells in the human body, and their unique properties give researchers the hope that from these primitive cells new therapies can result that may be available for future medical applications. We have created a multi-institutional training grant that will pool the resources and experience of stem cell scientists at 3 research institutes, 1 fertility clinic and 2 biotechnology companies in [REDACTED]. This multi-disciplinary team of scientists will be able to train and mentor trainees in basic research and translational development with the goal of providing a bench to bedside scope of experience. This will benefit California by training a new cadre of scientists capable of participating more fully in moving basic research discoveries into the medical clinic.