CIRM Center for Derivation of Pluripotent Stem Cell Lines

Funding Type: 
hiPSC Derivation
Grant Number: 
ID1-06576
Investigator: 
ICOC Funds Committed: 
$0
oldStatus: 
Closed
Public Abstract: 
Stem cell biology and regenerative medicine holds tremendous promise for addressing critical health needs through early diagnosis of disease, identification of potential pharmaceutical agents, and generation of novel stem cell-based therapies. In this project, we seek to overcome one impediment to current efforts in stem cell biology and regenerative medicine and that is the shortage of well-defined, large collections of induced pluripotent stem cell (iPSC) lines that have been derived under standard conditions in the same facility with the same protocols. To accomplish this large task, we have assembled a team that has experience in deriving nearly 500 lines that include those from unaffected individuals, and those affected by cardiac anomalies, neurodegenerative disease, autism, schizophrenia, peripheral vascular disease, diabetes, premature ovarian failure (autoimmune and unexplained), and diverse and less common pathologies. We have chosen a method to derive the lines based on its reliability, efficiency, and cost-effectiveness. We also propose a well-defined set of measures to insure the high-quality of the lines and present a plan for success within the 3 year timeframe.
Statement of Benefit to California: 
Stem cell biology and regenerative medicine holds tremendous promise for addressing critical health needs through early diagnosis of disease, identification of potential pharmaceutical agents, and generation of novel stem cell-based therapies. In this project, we seek to overcome one impediment to current efforts in stem cell biology and regenerative medicine and that is the shortage of well-defined, large collections of induced pluripotent stem cell (iPSC) lines that have been derived under standard conditions in the same facility with the same protocols. This project will enable unprecedented studies aimed at understanding human disease and tackling disease at its core. We focus our efforts on common conditions that affect many families in California including cardiac anomalies, neurodegenerative disease, autism, schizophrenia, peripheral vascular disease, diabetes, and also less common pathologies. The benefit to citizens will ultimately be realized through informed and earlier diagnosis combined with better treatments or more appropriate treatments based on knowledge of the disease/condition. Overall, the proposed research will contribute to our scientific infrastructure and technological growth, keeping California at the forefront, while contributing to advancement of better health care in individuals with diverse conditions.

© 2013 California Institute for Regenerative Medicine