Biomaterial Microenvironment Modeled Bioreactor

Funding Type: 
Tools and Technologies I
Grant Number: 
RT1-01067
Investigator: 
ICOC Funds Committed: 
$0
oldStatus: 
Closed
Public Abstract: 
The potential for use of stem cells in regenerative medicine has produced considerable excitement. While most of the current research in the area has focused on defining media components that control stem cell differentiation, relatively little attention has been paid to the problem of generating ideal in-vitro culture systems for optimal growth, and expansion of stem cells and their specific progenitors, for practical regenerative medicine applications. In addition, methods for expansion and propagation of stem cells and their progenies, available to date, collectively lack features to produce only a specific cell type either by a) Generation of specific lineage or cell types for harvest (subject of this proposal), and/or b) “Filtering” and separation of specific progenitors from all other cell types (not subject of this proposal, current in-house R&D). The overall objective of this project is to develop and demonstrate feasibility of a prototype bioreactor, modeling the in-vivo stem cell niche, for production of progenitor cells which are expanded and differentiated into specific tissue lineages (in the bioreactor) while maintaining a stable pool of stem cells for long-term production. Tools and technologies developed based on the proposed feasibility demonstration studies will provide the foundation required for development of new bioreactor based cell separation and purification methodologies for effective harvest of differentiated cell types away from undifferentiated cells (i.e. pivotal for safe and efficacious cell therapy and FDA approval). In addition, our commercialization strategies in partnership with larger “research tool” companies (currently in-progress) will generate commercial products for different sectors of this field, following successful accomplishment of the proposed studies.
Statement of Benefit to California: 
The potential for use of stem cells in regenerative medicine has produced considerable excitement. While most of the current research in the area has focused on defining media components that control stem cell differentiation, relatively little attention has been paid to the problem of generating ideal in-vitro culture systems for optimal growth, and expansion of stem cells and their specific progenitors, for practical regenerative medicine applications. Benefits for the state of California and its citizens: 1) Tools and technologies developed based on the proposed studies will provide the foundation required for upscale production of safe and efficacious cells for therapies facilitating translation to the clinic and FDA approval. 2) Our commercialization strategies in partnership with larger “research tool” companies (currently in-progress) will generate commercial products for different sectors of this field, advancing research and development enabling new regenerative cell therapies for uncured diseases.

© 2013 California Institute for Regenerative Medicine