Grant Award Details

Autologous cell therapy for Parkinson’s disease using iPSC-derived DA neurons
Grant Number: 
DISC2-09073
Project Objective: 
  • To further characterize the functionality and variability ofiPSC-derived dopaminergic neurons derived from Parkinson’s patients for thedevelopment of an autologous, cell-based therapy. 

Investigator: 
Type: 
PI
Disease Focus: 
Parkinson's Disease
Neurological Disorders
Human Stem Cell Use: 
iPS Cell
Cell Line Generation: 
iPS Cell
Award Value: 
$2,354,226
Status: 
Active

Grant Application Details

Application Title: 
  • Autologous cell therapy for Parkinson’s disease using iPSC-derived DA neurons
Public Abstract: 

Research Objective

Autologous human dopaminergic neurons derived from patient-specific induced pluripotent stem cells

Impact

Parkinson's disease

Major Proposed Activities

  • Characterize differentiation from all 10 patient cell lines
  • Characterize functionality of patient neurons matured in vitro
  • Immunogenicity assessment
  • Cryopreservation feasibility testing
  • Investigate dose response in vivo
  • Detect dopamine release in vivo
Statement of Benefit to California: 

Thousands of Californians suffer from the degenerative effects of Parkinson's disease, a disease for which there is no cure. There is hope, however, that stem cells could provide the key to providing long-term relief. Our study seeks to treat patients with cells derived from their own stem cells, a process which could be applied to other diseases such as diabetes and heart disease and could potentially be used to the benefit of many of the citizens of California.