It takes a PHD to SUMO.

Journal: 
Trends Biochem Sci
Publication Year: 
2008
Authors: 
Jamy Peng , Joanna Wysocka
Public Summary: 
Scientific Abstract: 
PHD fingers and bromodomains are found in close proximity to each other in many chromatin-associated proteins and can functionally synergize. Recently, it has been demonstrated that the PHD finger of the KAP1 co-repressor functions as an E3 SUMO ligase for the adjacent bromodomain. This PHD-mediated SUMOylation stabilizes the association of the bromodomain with the chromatin modifiers SETDB1 and the nucleosome remodeling and deacetylation (NuRD) complex, thereby promoting establishment of the silent gene expression state.

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