Synthetic surfaces for human embryonic stem cell culture.

Journal: 
J Biotechnol
Publication Year: 
2010
Authors: 
Poornima Kolhar , Venkata Ramana Kotamraju , Sherry T Hikita , Dennis O Clegg , Erkki Ruoslahti
Public Summary: 
Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions.
Scientific Abstract: 
Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions.

© 2013 California Institute for Regenerative Medicine