Gene regulatory mechanisms that control spinal neuron differentiation from hES cells.

Gene regulatory mechanisms that control spinal neuron differentiation from hES cells.

Funding Type: 
SEED Grant
Grant Number: 
RS1-00288
Award Value: 
$704,543
Disease Focus: 
Amyotrophic Lateral Sclerosis
Neurological Disorders
Spinal Muscular Atrophy
Neurological Disorders
Stem Cell Use: 
Embryonic Stem Cell
Status: 
Terminated
Public Abstract: 
Statement of Benefit to California: 
Progress Report: 

Year 1

The differentiation of stem cells into clinically-useful cell types is directly dependent on the accurate regulation of gene activation/repression. During the last scientific period we have focused our research on aim 2 of the grant proposal -– to characterize enzymes that are recruited to DNA for the regulation of genes. This effort has employed new DNA sequencing technologies to understand how the lysine specific demethylase (KDM1, LSD1) control gene expression in embryonic stem cells.

© 2013 California Institute for Regenerative Medicine