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Information about disease focus, human stem cell use or new cell line generation will typically not be available on the website until a few months after the award is announced. Disease categories are provided for awards that might impact a given disease or related area, whether those awards are for translational research on new therapy candidates or for basic research to address a biological question that is relevant to that disease.
Institution Researcher name Grant Type Grant Title ICOC Approved Funds
Escape Therapeutics, Inc Basil Hantash Transplantation Immunology Development of an immune tolerant hESC source for allogeneic cell therapy applications $1,453,040
Scripps Research Institute Carlos Barbas Tools and Technologies I Development of a novel technology for precise, efficient, and safe genetic modification of stem cells $1,146,312
Palo Alto Institute for Research and Education, Inc. Husein Hadeiba Transplantation Immunology Application of Tolerogenic Dendritic Cells for Hematopoietic Stem Cell Transplantation $1,328,213
Scripps Research Institute Jeanne Loring Tools and Technologies I The Stem Cell Matrix: a map of the molecular pathways that define pluripotent cells $1,141,124
Gamma Medica-Ideas, Inc. Douglas Wagenaar Tools and Technologies I A Novel SPECT Microscopy System for 3D Imaging of Single Stem Cells In Vivo $949,748
Beckman Research Institute of City of Hope Larry Couture Tools and Technologies I Development of Suspension Adaptation, Scale-up cGMP Banking and Cell Characterization Technologies for hESC Lines $882,929
University of California, San Francisco Mark Anderson Transplantation Immunology Stem cell differentiation to thymic epithelium for inducing tolerance to stem cells $1,314,090
University of California, San Diego Steve Dowdy Tools and Technologies I TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells $925,200
La Jolla Institute for Allergy and Immunology Anjana Rao Transplantation Immunology Generation of regulatory T cells by reprogramming $1,503,998
University of California, Santa Barbara Dennis Clegg Tools and Technologies I Synthetic Matrices for Stem Cell Growth and Differentiation $599,998
University of California, Davis William Murphy Transplantation Immunology Donor natural killer (NK) cells as “veto” cells to promote donor-specific tolerance $1,317,569
University of California, San Diego Ying Liu Tools and Technologies I Generation of disease models for neurodegenerative disorders in hESCs by gene targeting $869,262
Stanford University Christopher Contag Transplantation Immunology Engineering Embryonic Stem Cell Allografts for Operational Tolerance $1,447,956
ViaCyte, Inc. Evert Kroon Tools and Technologies I Development of the Theracyte Cellular Encapsulation System for Delivery of human ES Cell-derived Pancreatic Islets and Progenitors. $827,072
Cedars-Sinai Medical Center Terrence Town Transplantation Immunology Role of HLA in neural stem cell rejection using humanized mice $1,472,634
Fluidigm Corporation Marc Unger Tools and Technologies I Scaleup of Versatile, Fully Automated, Microfluidic Cell Culture System $749,520
ViaCyte, Inc. Olivia Kelly Early Translational I Methods for detection and elimination of residual human embryonic stem cells in a differentiated cell product $5,405,397
University of California, Merced Michael Cleary Tools and Technologies I RNA Analysis by Biosynthetic Tagging (RABT): a tool for the identification of cell type-specific RNAs $483,803
Stanford University Judith Shizuru Transplantation Immunology Purified allogeneic hematopoietic stem cells as a platform for tolerance induction $1,403,557
Scripps Health Darryl D'Lima Early Translational I Stem Cell-Based Therapy for Cartilage Regeneration and Osteoarthritis $3,118,431
University of California, Santa Cruz Joel Kubby Tools and Technologies I AO Wide-Field Microscope $552,985
University of California, San Francisco Jeffrey Bluestone Transplantation Immunology Stem cell tolerance through the use of engineered antigen-specific regulatory T cells $1,152,768
Scripps Research Institute Martin Friedlander Early Translational I Autologous Retinal Pigmented Epithelial Cells Derived from Induced Pluripotent Stem Cells for the Treatment of Atrophic Age Related Macular Degeneration $5,945,738
University of California, Irvine Orhan NALCIOGLU Tools and Technologies I A Multimodality Molecular Imaging Systen (MRSPECT) for in Vivo Stem Cell Tracking $719,798
The J. David Gladstone Institutes Warner Greene Early Translational I Maximizing the Safety of Induced Pluripotent Stem Cells as an Infusion Therapy: Limiting the Mutagenic Threat of Retroelement Retrotransposition during iPSC Generation, Expansion and Differentiation $1,327,973
University of California, Los Angeles Michael Phelps Tools and Technologies I Novel Tools and Technologies for Translational PET Imaging of Cell-based Therapies $914,096
University of California, San Diego Martin Marsala Transplantation Immunology Induction of immune tolerance after spinal grafting of human ES-derived neural precursors $1,387,800
The Jackson Laboratory West Leon Hall Early Translational I Mouse Models for Stem Cell Therapeutic Development $3,841,240
Vala Sciences, Inc. Patrick McDonough Tools and Technologies I Optimization in the Identification, Selection and Induction of Maturation of Subtypes of Cardiomyocytes derived from Human Embryonic Stem Cells $906,629
Stanford University Robert Negrin Transplantation Immunology Regulatory T cell induced tolerance to ESC transplantation $1,427,980
The Parkinson's Institute J. William Langston Early Translational I Using patient-specific iPSC derived dopaminergic neurons to overcome a major bottleneck in Parkinson's disease research and drug discovery $3,701,766
University of California, Berkeley Steven Conolly Tools and Technologies I Magnetic Particle Imaging: A Novel Ultra-sensitive Imaging Scannerfor Tracking Stem Cells In Vivo $882,430
VistaGen Therapeutics, Inc. Kristina Bonham Tools and Technologies I Development of an hES Cell-Based Assay System for Hepatocyte Differentiation Studies and Predictive Toxicology Drug Screening $971,558
University of California, Davis Alice Tarantal Tools and Technologies I In Vivo Imaging for the Detection and Quantitation of Transplanted Stem/Progenitor Cells in Nonhuman Primates $842,149
Scripps Research Institute Nicholas Gascoigne Transplantation Immunology Role of Innate Immunity in hematopoeitic stem cell-mediated allograft tolerance $1,746,684
University of California, Berkeley David Schaffer Tools and Technologies I Directed Evolution of Novel AAV Variants for Enhanced Gene Targeting in Pluripotent Human Stem Cells and Investigation of Dopaminergic Neuron Differentiation $918,000
University of Southern California Pin Wang Tools and Technologies I Development of Baculoviral Vectors for Gene Editing of Human Stem Cells $951,104
University of California, Berkeley Ellen Robey Transplantation Immunology Human Immune System Mouse models as preclinical platforms for stem cell derived grafts $1,079,393
University of California, Los Angeles Hsian-Rong Tseng Tools and Technologies I Microfluidic Platform for Screening Chemically Defined Conditions that Facilitate Clonal Expansion of Human Pluripotent Stem Cells $914,096
University of California, Irvine Lisa Flanagan Tools and Technologies I Novel Separation of Stem Cell Subpopulations $871,627
Stanford University Helen Blau Tools and Technologies I Regulation of Stem Cell Fate in Bioengineered Arrays of Hydrogel Microwells $949,608
The Salk Institute for Biological Studies Beverly Emerson SEED Grant Regulation of Specific Chromosomal Boundary Elements by CTCF Protein Complexes in Human Embryonic Stem Cells $678,788
Stanford University Thomas Wandless SEED Grant Reprogramming Differentiated Human Cells to a Pluripotent State $647,681
Stanford University Joachim Hallmayer Tissue Collection for Disease Modeling Induced pluripotent stem cells from children with autism spectrum disorders $530,265
University of California, Los Angeles Brigitte Gomperts Tissue Collection for Disease Modeling Using human induced pluripotent stem cells to improve our understanding of Idiopathic Pulmonary Fibrosis $934,515
Stanford University Joseph Wu Tissue Collection for Disease Modeling Tissue Collection for Accelerating iPSC Research in Cardiovascular Diseases $1,435,371
University of California, San Diego Kang Zhang Tissue Collection for Disease Modeling Generation of fibroblast cell lines in patients with common blinding eye diseases $1,034,452
University of California, San Diego Joseph Gleeson Tissue Collection for Disease Modeling CIRM Tissue Collection for Neurodevelopmental Disabilities $874,135
University of California, San Francisco Jacquelyn Maher Tissue Collection for Disease Modeling iPSC-derived Hepatocytes as Platforms for Research in Viral Hepatitis and Non-alcoholic Steatohepatitis $865,370
University of California, San Diego Douglas Galasko Tissue Collection for Disease Modeling Collection of skin biopsies to prepare fibroblasts from patients with Alzheimer's disease and cognitively healthy elderly controls $643,693
Cellular Dynamics International Thomas Novak hiPSC Derivation Generation and characterization of high-quality, footprint-free human induced pluripotent stem cell lines from 3,000 donors to investigate multigenic diseases $16,000,000
Coriell Institute for Medical Research Steven Madore hPSC Repository The CIRM Human Pluripotent Stem Cell Biorepository – A Resource for Safe Storage and Distribution of High Quality iPSCs $9,999,834
Total:
$93,989,379.00

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