Summaries of Review for Applications to RFA 08-05

Review summaries for RFA 08-05: CIRM Early Translational Research Awards

The following is a listing of all applications reviewed under RFA 08-05 for CIRM Early Translational Research Awards. Applications include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Grants Working Group (GWG) during the review meeting on February 9, 10 & 11, 2009. A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.
 
= Recommended for funding
 
= Recommended if funds available
 
= Not Recommended for funding at this time

 

Application Number

ICOC Decision

Title

Scientific Score
TR1-01249 Approved Enhancing healing via Wnt-protein mediated activation of endogenous stem cells 94
TR1-01246 Approved Using patient-specific iPSC derived dopaminergic neurons to overcome a major bottleneck in Parkinson's disease research and drug discovery 87
TR1-01215 Approved Methods for detection and elimination of residual human embryonic stem cells in a differentiated cell product 85
TR1-01257 Approved Sustained siRNA production from human MSC to treat Huntington’s Disease and other neurodegenerative disorders 85
TR1-01273 Approved Curing Hematological Diseases 85
TR1-01216 Approved Stem Cell-Based Therapy for Cartilage Regeneration and Osteoarthritis 84
TR1-01245 Approved Neural Stem Cells as a Developmental Candidate to Treat Alzheimer's Disease 84
TR1-01272 Approved Development of a Stem Cell-based Transplantation Strategy for Treating Age-related Macular Degeneration 84
TR1-01219 Approved Autologous Retinal Pigmented Epithelial Cells Derived from Induced Pluripotent Stem Cells for the Treatment of Atrophic Age Related Macular Degeneration 81
TR1-01276 Approved Addressing the Cell Purity and Identity Bottleneck Through Generation and Expansion of Clonal Human Embryonic Progenitor Cell Lines 81
TR1-01227 Approved Maximizing the Safety of Induced Pluripotent Stem Cells as an Infusion Therapy: Limiting the Mutagenic Threat of Retroelement Retrotransposition during iPSC Generation, Expansion and Differentiation 79
TR1-01267 Approved "Developmental Candidates" for Cell-Based Therapies for Parkinson's Disease (PD) 79
TR1-01250 Approved Ensuring the safety of cell therapy: a quality control pipeline for cell purification and validation 78
TR1-01277 Approved Developing induced pluripotent stem cells into human therapeutics and disease models 77
TR1-01269 Approved In Utero Model to Assess the Fate of Transplanted Human Cells for Translational Research and Pediatric Therapies 77
TR1-01274 -- Multipotent stem cells and renal progenitors derived from amniotic fluid as potential tools for chronic kidney disease therapies 72
TR1-01200 -- Development of Cell Therapy for Epilepsy 69
TR1-01212 -- Development of a device for the identification and quantification of cancer stem cells 71
TR1-01214 -- Pluripotent stem cells for regenerating and regulating immunity 70
TR1-01229 -- Treatment of Sickle Cell Anemia and Thalassemia 70
TR1-01236 -- Targeting Cancer Stem Cells Via Small Molecule CBP/beta-Catenin Antagonists 70
TR1-01204 -- Overcoming the Translational Challenges of Using Pluripotent Stem Cells for Therapy in an Ischemic Cardiomyopathy Model 69
TR1-01265 -- Depletion of Teratoma-Forming Cells for hESC-Based Transplantation Technologies 69
TR1-01226 -- Adult Stem Cells from Human Uterus and Novel Biomaterials for Pelvic Floor Regeneration 68
TR1-01228 -- Identification of cancer stem cell-specific internalizing scFvs for pre-clinical antibody-drug conjugate development 67
TR1-01232 Approved Mouse Models for Stem Cell Therapeutic Development 66
TR1-01266 -- Stem Cell Transplantation for Pediatric Neurodegenerative Disease 66
TR1-01211  -- Building complex tissues: Converting Dissociated Stem Cells into Hair Organs for Burn Patients -
TR1-01255  -- Screening and Development of Novel Therapeutics for Sickle Cell Disease and Thalassemia -
TR1-01271  -- Identification of an ES cell-based development candidate for Huntington's disease -
TR1-01258  -- Hepatic progenitors from human pluripotent stem cells for research and therapy -
TR1-01223  -- Novel Small Molecules for Stem Cell-based Therapies -
TR1-01263  -- A Double Edged Sword - Cell Death & Proliferation: A Major Bottleneck for Stem Cell-Based Applications -
TR1-01205  -- Towards hES cell therapy for Type 1 diabetes -
TR1-01242  -- Overcoming Bottlenecks to Cardiac Regenerative Therapy -
TR1-01206  -- Bone Marrow-Derived SB618 Cells for Re-myelination Therapy -
TR1-01268 -- Adult human pancreatic endocrine stem cells: Induction of beta-cell differentiation through chemical genomics and transplantation of encapsulated cells as an integrated approach to the treatment of type I diabetes -
TR1-01209  -- Development of Therapeutic Monoclonal Antibodies to Myeloid Leukemia Cancer Stem Cells -
TR1-01218  -- Reprogramming of Adult Cells into Transplantable Stem Cells -
TR1-01252  -- Isolation, purification, cryopreservation, expansion, differentiation and characterization of homogeneous populations of cells derived from the placenta and amnion for therapeutic use. -
TR1-01244  -- Human Embryonic Stem Cell Therapy for Type I Diabetes -
TR1-01234  -- Development and Clinical Implementation of Ultra-high Speed Cell Sorting for Regenerative Medicine Applications -
TR1-01262  -- Dual stem cell transplantation in tissue engineered scaffolds for the repair of spinal cord injury -
TR1-01239  -- Human Cardiac Progenitors for Autologous Cell-Based Therapy -
TR1-01275  -- Towards a patient-specific, pluripotent cell-based therapy for Parkinson's disease -
TR1-01230  -- Prevention and Treatment of Teratoma Formation During Stem Cell Therapy -
TR1-01208  -- Microfluidics-based protocol for differentiation of human ESCs to hepatic cells -
TR1-01261  -- Development of nanoscale genomic methods for tracking of stem cell transplants. -
TR1-01207  -- Enhanced ESC-derived DA Neuronal Cells for Treating Parkinson’s Disease -
TR1-01221  -- Novel Strategy to Enhance T cell Reconstitution Post Stem Cell Transplantation -
TR1-01240  -- Generation of patient-specific cells -
TR1-01253  -- Generation and comprehensive characterization of induced pluripotent stem cells from somatic adult cells, without the use of viral vectors. -
TR1-01202  -- Model development using malignant pleural effusions for extracting and validating lung cancer stem cells. -
TR1-01278  -- Pluripotent Cell Transplantation Induced Teratoma Prevention -
TR1-01201  -- Accelerated Repair of Vascular Injury in Diabetic Retinopathy by Autologous TGF-Beta-Modified Hematopoietic Stem Cells -
TR1-01203  -- Characterization of Cancer Stem Cells in Multiple Myeloma -
TR1-01248  -- Stem Cells and Biomimetic Nano-Matrix for Vascular Regeneration -
TR1-01251  -- A universal ex vivo/in vivo hybrid platform for the in situ tracking of behavior and fate determination of defined stem cell populations: A bridge towards clinical application of stem cell therapy for CNS pathology -
TR1-01254  -- Thymic Regeneration as a Strategy to Induce Immunological Tolerance to ESC-Derived Therapies -
TR1-01217  -- Developmental candidate: hESC derived therapies for neonatal urea cycle defects -
TR1-01270  -- Stem cell differentiation therapy for melanoma using human experienced drugs -
TR1-01279  -- Repairing Corneal Epithelium Using MicroRNA-Induced Embryonic-Like Stem Cells -
TR1-01241  -- Generation and Validation of Clinical Grade Stem Cell Lines for Human Trials in California. -
TR1-01243  -- Optimizing Sorting Flow Cytometry for Translational Stem Cell Therapies -
TR1-01237  -- Comparative Studies of Subcutaneous, Omental, and Portal Islet Transplantation Sites -
TR1-01213  -- Production of Dopaminergic Neurons for Cell Therapy in Parkinson’s Disease -
TR1-01231  -- Selection, maturation induction and enrichment of pacemaker cells from stem cells for generating biological pacemakers in clinical therapy -
TR1-01222  -- Development of a Myocardial Repair Patch (MRP) -
TR1-01233  -- Universal MSCs for the prevention of type I diabetes progression -