Summaries of Review for Applications to RFA 08-02

The following is a listing of all applications reviewed under RFA 08-02 for CIRM Tools And Technologies Awards. Applications include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Grants Working Group (GWG) during the review meeting on September 8-10, 2008. A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.
 
= Recommended for funding
 
= Recommended if funds available
 
= Not Recommended for funding

 
Application Number ICOC Decision Title Scientific Score
RT1-01021-1 Approved Directed Evolution of Novel AAV Variants for Enhanced Gene Targeting in Pluripotent Human Stem Cells and Investigation of Dopaminergic Neuron Differentiation 90
RT1-01028-1 Approved Development of Baculoviral Vectors for Gene Editing of Human Stem Cells 88
RT1-01143-1 Approved Optimization in the Identification, Selection and Induction of Maturation of Subtypes of Cardiomyocytes derived from Human Embryonic Stem Cells 87
RT1-01024-1 Approved Scaleup of Versatile, Fully Automated, Microfluidic Cell Culture System 86
RT1-01074-1 Approved Novel Separation of Stem Cell Subpopulations 86
RT1-01103-1 Approved Development of a novel technology for precise, efficient, and safe genetic modification of stem cells 86
RT1-01022-1 Approved Microfluidic Platform for Screening Chemically Defined Conditions that Facilitate Clonal Expansion of Human Pluripotent Stem Cells 85
RT1-01055-1 Approved Magnetic Particle Imaging: A Novel Ultra-sensitive Imaging Scanner for Tracking Stem Cells In Vivo 85
RT1-01012-1 Approved Development of an hES Cell-Based Assay System for Hepatocyte Differentiation Studies and Predictive Toxicology Drug Screening 84
RT1-01107-1 Approved Generation of disease models for neurodegenerative disorders in hESCs by gene targeting 84
RT1-01001-1 Approved Regulation of Stem Cell Fate in Bioengineered Arrays of Hydrogel Microwells 83
RT1-01052-1 Approved RNA Analysis by Biosynthetic Tagging (RABT): a tool for the identification of cell type-specific RNAs 83
RT1-01063-1 Approved TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells 83
RT1-01097-1 Approved Discovery of adhesion ligands for pluripotent human stem cells 83
RT1-01019-1 Approved In Vivo Imaging for the Detection and Quantitation of Transplanted Stem/Progenitor Cells in Nonhuman Primates 82
RT1-01120-1 Approved A MULTI-MODALITY MOLECULAR IMAGING SYSTEM (MRSPECT) FOR IN VIVO STEM CELL TRACKING 82
RT1-01057-1 Approved Development of Suspension Adaptation, Scale-up cGMP Banking and Cell Characterization Technologies for hESC Lines 81
RT1-01053-1 Approved Synthetic Matrices for Stem Cell Growth and Differentiation 80
RT1-01093-1 Approved Development of the [REDACTED] Cellular Encapsulation System for Delivery of human ES Cell-derived Pancreatic Islets and Progenitors. 80
RT1-01126-1 Approved Novel Tools and Technologies for Translational PET Imaging of Cell-based Therapies 80
RT1-01108-1 Approved The Stem Cell Matrix: a map of the molecular pathways that define pluripotent cells 77
RT1-01027-1 Approved A Novel SPECT Microscopy System for 3D Imaging of Single Stem Cells In Vivo 76
RT1-01095-1 Approved AO Wide-Field Microscope 76
RT1-01050-1 -- Technology platform to develop defined culture conditions for the derivation and expansion of hESC lines 71
RT1-01062-1 -- Discovery and optimization of small molecules for stem cell fate regulation 71
RT1-01144-1 -- Proteomic Technologies for Systems-Level Assessment of Self-Renewal of Embryonic Stem Cells and differentiation to 2º hNSCs 77
RT1-01073-1 -- Production of an Antibody Toolkit for Characterizing Human Embryonic Stem Cells and Their Differentiated Progeny 77
RT1-01122-1 -- Development of Genomics and Bioinformatics Tools to Elucidate Alternative Splicing and Gene Expression Networks in Human Embryonic Stem Cells 76
RT1-01082-1 -- Generation of induced pluripotent stem cells free of retroviral DNA 73
RT1-01084-1 -- Production of stable pluripotent selectable hES/iPS cell lines for site-specific integration of BAC reporter constructs 73
RT1-01094-1 -- Human ESCs as Cellular Tools for Drug Discovery 73
RT1-01130-1 -- Tracking of Human Embryonic Stem Cell Differentiation and Migration 73
RT1-01056-1 -- Non-Viral Strategies for Nuclear Reprogramming 71
RT1-01049-1 -- Using modern proteomic and molecular tools to identify novel MSC and hESC lineage specific membrane markers: Development of new antibodies for live cell imaging and isolation 70
RT1-01006-1 -- Reagents That Control Stem Cell Differentiation 69
RT1-01033-1 -- Site-Specific Gene Insertion into ES Cells with Pre-Selected Loci 69
RT1-01064-1 -- Nano/Micro Technology Platform for the Promotion of Lineage Specific Differentiation of Pluripotent Stem Cells 69
RT1-01048-1 -- Assay-ready screening plates seeded with high purity hESC-derived human cell populations 68
RT1-01070-1 -- STEM CELL ACTIVITY IN THE NEWBORN BRAIN: NON-INVASIVE QUANTITATIVE AND AUTOMATED ASSESSMENT USING MRI 68
RT1-01110-1 -- Regulatable genetic modifications of HESC for in vivo imaging and safety monitoring of implanted HESC: applications to neurodegeneration models 63
RT1-01002-1 -- Fluorescent reporters for monitoring key transcriptional control steps in the differentiation of human embryonic stem cells into T cells --
RT1-01004-1 -- Endomyocardial Catheter Delivery of Artificial Biopolymer Matrices for Enhanced Cell Retention in Cardiovascular Cell Based Therapy. --
RT1-01005-1 -- Establishment of novel defined culture conditions for human embryonic stem cells and induced pluripotent stem cells --
RT1-01008-1 -- Tools for the study of hair cell regeneration in the inner ear. --
RT1-01009-1 -- Cryopreservation of human placenta --
RT1-01010-1 -- Human Marrow Stromal Mesenchymal Progenitor Cell Lines from Patients with Distinct Hematopoietic Diseases --
RT1-01011-1 -- Development of a Novel DTI-MRI Tool to Monitor Remyelination in Multiple Sclerosis following Stem Cell Injection --
RT1-01015-1 -- New Cryoprotective Tools For hES Cells and hEP Cells --
RT1-01016-1 -- Rapid development of human antibodies to stem cell proteins using scFv yeast & phage display --
RT1-01017-1 -- Development of Engineered hES cell lines suitable for antibiotic selection of cardiomyocytes. --
RT1-01018-1 -- Development of a Technology to Increase the Availability of Human Oocytes for Use in Regenerative Medicine --
RT1-01020-1 -- A biophotonic laser-assisted cell surgery tool (BLAST) --
RT1-01023-1 -- Evaluation of Suspension Culture of Cell Aggregates as a Method to Expand Human Embryonic Stem Cells to Clinically Viable Scale --
RT1-01025-1 -- Development of novel vectors for generating human induced pluripotent stem (iPS) Cells --
RT1-01026-1 -- Development of High Throughput Functional Genomics Screening in Stem Cells --
RT1-01029-1 -- Development of multiparameter based flow cytometry technology for characterization and isolation of purified population of hESC derived differentiated cells for use in cell therapy - pilot system with cholinergic neurons. --
RT1-01030-1 -- Establishment of a Stem Cell Monoclonal Antibody and Tissue Array Facility --
RT1-01031-1 -- Systematic generation and molecular characterization of hES-derived cell strains utilizing combinatorial cloning. --
RT1-01032-1 -- Genetically modified human ES cells as novel tools for developing human cell replacement therapy --
RT1-01034-1 -- Direct protein induction of pluripotent stem cells from human fibroblasts --
RT1-01035-1 -- Developing dopaminergic reporter hESC lines by homologous recombination --
RT1-01036-1 -- Evaluate Rapamycin as Powerful hESC Differentiation Tool for Pre-clinical and Clinical Application --
RT1-01038-1 -- Innovative Stem Cell Tools for Parkinson's Assay Development --
RT1-01039-1 -- Development of a 3D ESC Culturing Process: Considerations on Stem Cell Fate Decisions Induced by Shear Stress Stimulation (SISSi) --
RT1-01040-1 -- Development and Evaluation of Human Stem Cell-Derived Neurons for High-Throughput, Automated Electrophysiology. --
RT1-01041-1 -- An innovative tool for high throughput, cost-effective monitoring of chromosomal abnormalities in stem cells --
RT1-01042-1 -- Stabilization of human embryonic stem cells at higher yields and temperatures than currently possible --
RT1-01044-1 -- Novel Stem Cell-Derived AAV Capsids for Gene Transfer to Human Embryonic Stem Cells --
RT1-01046-1 -- Ratio-fluorescence miRNA Sensors for Tracking and Isolating Stem and Progenitor Cells --
RT1-01047-1 -- Molecular analysis of single neural progenitor cells during brain development --
RT1-01051-1 -- Discovery and validation of biomarkers to myeloid leukemia cancer stem cells by the generation of monoclonal antibodies --
RT1-01054-1 -- High-throughput, label-free stem cell sorting using shear-rate discrimination --
RT1-01060-1 -- Development of Prognostic, Therapy Selection and Therapy Targeting Markers for Adult Breast Cancer Peripheral Blood Stem Cells. --
RT1-01061-1 -- Development of Optimal Approaches for Genomic Engineering of Human Stem Cells --
RT1-01066-1 -- Development of Technologies Toward Cardiac Repair with Human Embryonic Stem Cells --
RT1-01067-1 -- Biomaterial Microenvironment Modeled Bioreactor --
RT1-01068-1 -- Improved Humanized Liver Model for Human Embryonic Stem Cell Therapeutic Transplantation Research --
RT1-01069-1 -- Development of Diagnostics to Assess Potential Teratoma Tumorigenicity in Human Stem Cell Derived Therapeutics --
RT1-01071-1 -- Development of Tools for Discovery of Allele-Specific Epigenetic Regulatory Elements in Human Embryonic Stem Cells and Their Derivatives --
RT1-01072-1 -- Mesoscopic Multimode Molecular Imaging for In Vivo tracking of stem cells --
RT1-01076-1 -- Tools to Enable Bone Marrow Stem Cell Derived Regenerative Medicine: Harvest, Processing & Delivery --
RT1-01079-1 -- Genetically engineered immune tolerant human beta cells --
RT1-01080-1 -- Developing fluorescent quantum dots as tools to study the dynamic organization of pluripotent chromatin in embryonic stem cells --
RT1-01081-1 -- Platform for automated growth, imaging, and sorting of stem cells --
RT1-01085-1 -- Tool for epigenetic analysis of cancer stem cells and other rare stem cell populations --
RT1-01086-1 -- Development of monoclonal antibody reagents and peptide tools for the identification and characterization of human embryonic stem cells. --
RT1-01087-1 -- Next-Generation Sequencing for Discovery of Biomarkers of Pluripotence --
RT1-01088-1 -- Development of a Novel Technology for Cryopreservation of Human Embryonic Stem Cells in Adherent State --
RT1-01090-1 -- Gene Targeting in Human Embyronic Stem Cells --
RT1-01091-1 -- Lentiviral Vectors for Optimal Gene Expression in Human Pluripotent Stem Cells --
RT1-01096-1 -- Engineering Platforms for The Creation Of Lineage-Rainbow Reporter Lines In Human Embryonic Stem Cells --
RT1-01098-1 -- Ligand-Targeted Phage Particles as Tools for Progenitor Cell Tracking, Gene Delivery, and Biomarker Discovery --
RT1-01100-1 -- Antibody targeting of stem cells and stem cell modifiers for tissue regeneration --
RT1-01101-1 -- “Differential proteomic panning analysis of protein from single stem cells: An alternative to mass spectrometric methods” --
RT1-01102-1 -- Development of Multi-fluorescent Protein Markers for Stem Cell Fate Tracking in vitro and in vivo --
RT1-01104-1 -- Development of non integrating gene delivery system for reprogramming adult cells and identify molecules to enhance reprogramming efficiency --
RT1-01106-1 -- Early Predictors of Cell Fate Commitment by Embryonic Stem Cells: Cell Identification through Signaling Network Analysis in hESC Differentiation --
RT1-01109-1 -- Long-term Organotypic Slice Model: A novel ex vivo culture system for the in situ study of stem cell and cancer cell biology in the brain and spinal cord --
RT1-01115-1 -- Optimization and Characterization of Human Induced Pluripotent Stem Cell Production --
RT1-01116-1 -- A three dimensional perfusion device for building networks of blood vessels for exploring the limits of vascular tissue engineering, chemotaxis, and stem cell homing. --
RT1-01117-1 -- Development of a Targeting and Signal Transduction System for Stem Cell Programming --
RT1-01118-1 -- Development of a Dielectrophoretic System for Rapid and Efficient Stem Cell Separation --
RT1-01121-1 -- Derivation of hepatic lineage cells from embryonic stem cells following differentiation in 3D liver microenvironmental cell cultures for large-scale application to cell and tissue tools, devices, diagnostics and therapeutics --
RT1-01123-1 -- A flexible system for the safe, rapid, and efficient isolation and sensitive biosafety testing of hESC derivatives, leading to FDA-approved products for cellular therapies --
RT1-01124-1 -- Safety Implications of Epigenetic and Genetic Adaptation of Human Embryonic Stem Cells to Culture In Vitro --
RT1-01125-1 -- A new microarray tool for discovering DNA methylation stem cell biomarkers --
RT1-01127-1 -- Improvement of Induced Pluripotent Stem Cell as a Tool for Clinical use in Cardiology --
RT1-01128-1 -- Next Generation Sequencing for Nanoscale Functional Analysis of Stem Cells --
RT1-01129-1 -- Integrated Single Cell Manipulation System --
RT1-01131-1 -- Biomarkers for Adult Human Pancreatic Endocrine Stem/Progenitor Cells --
RT1-01132-1 -- Novel Highly Accurate Single Cell Genotyping Technology for use in Discovering Late Onset Disease-Specific Stem Cell Lines and Monitoring Aneuploidy in Developing Stem Cell Lines --
RT1-01134-1 -- Development of methods for gene targeting in human ES cells --
RT1-01135-1 -- A cell cultivation microsystem for directing hepatic differentiation of hESCs --
RT1-01137-1 -- Parthenogenetic Stem Cell-Derived Corneal Tissue as an In Vitro Model for Ocular Injury --
RT1-01138-1 -- Angiogenesis: Development of a Novel Cell Separation Platform for Processing Bone Marrow and its Verification in a Prospective Randomized Clinical Trial of Critical Limb Ischemia --
RT1-01139-1 -- Magnetic Resonance Tracking of Iron Oxide Labeled Mesenchymal Stem Cells for Cartilage Tissue Engineering --
RT1-01140-1 -- Propagation, Characterization, and Distribution of Adult Stem Cells --
RT1-01141-1 -- Detection and Elimination of An Antigenic Non-Human Sialic Acid in Human Embryonic Stem Cells --