Summaries of Review for Applications to RFA 08-01

The following is a listing of all applications reviewed under RFA 08-01 for CIRM New Faculty 2 Awards. Applications include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Grants Working Group (GWG) during the review meeting on June 5-6, 2008. A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number. 
 
= Recommended for funding
 
= Recommended if funds available
 
= Not Recommended for funding


Application Number ICOC Decision Title Scientific Score
RN2-00906-1 Approved Mechanisms of small RNA regulation in early embryonic development 90
RN2-00919-1 Approved High throughput modeling of human neurodegenerative diseases in embryonic stem cells 89
RN2-00915-1 Approved Mechanisms in Choroid Plexus Epithelial Development 86
RN2-00934-1 Approved Mechanisms Underlying the Responses of Normal and Cancer Stem Cells to Environmental and Therapeutic Insults 86
RN2-00916-1 Approved Skeletogenic Neural Crest Cells in Embryonic Development and Adult Regeneration of the Jaw 84
RN2-00933-1 Approved Laying the groundwork for building a tooth: analysis of dental epithelial stem cells 82
RN2-00940-1 Approved The molecular basis underlying adult neurogenesis during regeneration and tissue renewal 82
RN2-00923-1 Approved The roles of non-coding RNAs in the self-renewal and differentiation of pluripotent stem cells 81
RN2-00922-1 Approved Molecular mechanisms governing hESC and iPS cell self-renewal and pluripotency 79
RN2-00908-1 Approved Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins 78
RN2-00938-1 Approved Mechanisms Underlying the Diverse Functions of STAT3 in Embryonic Stem Cell Fate Regulation 78
RN2-00931-1 Approved Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal 77
RN2-00903-1 Approved Induction of cardiogenesis in pluripotent cells via chromatin remodeling factors 76
RN2-00904-1 Approved Stem Cells in Lung Cancer 76
RN2-00945-1 Approved A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment 76
RN2-00910-1 Approved Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells 74
RN2-00946-1 Approved Mechanism of Tissue Engineered Small Intestine Formation 71
RN2-00950-1 Approved Molecular dissection of adult liver regeneration to guide the generation of hepatocytes from pluripotent stem cells 71
RN2-00921-1 Approved Building Cardiac Tissue from Stem Cells and Natural Matrices 68
RN2-00909-1 Approved VEGF signaling in adventitial stem cells in vascular physiology and disease 67
RN2-00905-1 Approved Mechanisms of chromatin dynamics at enhancers during ES cell differentiation 76
RN2-00902-1 Approved Stem Cells for Immune System Regeneration to Fight Cancer 71
RN2-00952-1 Approved Defining the Isoform-Specific Effects of Apolipoprotein E on the Development of iPS Cells into Functional Neurons in Vitro and in Vivo 71
RN2-00914-1 -- The Role of Stem Cells in Cartilage Repair and Regeneration 65
RN2-00936-1 -- Epicardial progenitor cells in cardiac regeneration. 65
RN2-00900-1 -- Prostate Cancer Stem Cells And Telomerase: Therapeutic Targeting And Clinical Significance 63
RN2-00943-1 -- Hematopoietic differentiation of human pluripotent stem cells 63
RN2-00918-1 -- Craniosynostosis and the role of stem/progenitor cells in premature suture fusion and accelerated bone formation 62
RN2-00907-1 -- Patient-specific pluripotent cell lines in Parkinson’s disease --
RN2-00911-1 -- Characterizing the Molecular Mechanisms of Pluripotent Stem Cell Self-Renewal --
RN2-00912-1 -- Stem Cells and Induction of Lesion-Induced Neural Circuit Reorganization --
RN2-00925-1 -- Epigenetic control of human embryonic stem cell (hESC) commitment and differentiation to skeletal muscles --
RN2-00913-1 -- Redox Mechanisms of Human Neural Stem Cell Differentiation: Implications for Malignant Brain Tumor Treatment --
RN2-00917-1 -- Development of high-throughput screening platform for directing hESCs into pancreatic progenitor cells and mature pancreatic beta cells --
RN2-00920-1 -- Biological Functions of Neural Stem Cells in the Adult Forebrain --
RN2-00924-1 -- Embryonic Animal Model for Generation of Retinal/RPE Precursors from Human Stem Cells --
RN2-00926-1 -- Effect of Microenvironment on Stem Cell Plasticity --
RN2-00927-1 -- Therapeutic Regeneration of Skeletal and Smooth Muscles in Female Pelvic Floor Disorders with Human Muscle-Derived Stem Cells in Animal Models. --
RN2-00928-1 -- Investigation of the Potential of Mouse Embryonic Stem Cells to Develop into Neuroendocrine Cells in Vitro --
RN2-00929-1 -- Optimizing grafts for in utero transplantation through study of the changing potentials of hematopoietic stem cells in early ontogeny --
RN2-00930-1 -- Targeting Cancer Stem Cells for Immunotherapy --
RN2-00932-1 -- Characterization of Placenta-Derived Stem Cells Using Raman Spectroscopy --
RN2-00935-1 -- Inducement, Characterization and Targeting of Human Cancer Stem Cells --
RN2-00937-1 -- Mechanisms of neural stem cell self-renewal and differentiation in the brain and cancer --
RN2-00939-1 -- Directed Stem Cell Recruitment into the CNS in Response to Coxsackievirus Infection --
RN2-00941-1 -- Lung Cancer Initiating Cells (LCIC) from Malignant Pleural Effusion (MPE) and Dendritic Cells (DC) mediated immunotherapy strategies. --
RN2-00942-1 -- Neural Progenitors and Alzheimer's Disease --
RN2-00944-1 -- Targeting mechanisms of stem cells for malignant brain tumors --
RN2-00947-1 -- Toward Our Understanding of the Stem Cell Epigenome: Assessment of Epigenetic Alterations During Human Adult Adipose Derived Stromal Cells (ADSCs) Aging. --
RN2-00948-1 -- Human placental stem cells --
RN2-00949-1 -- Targeting bone homing of osteoprogenitors by high-affinity ligands to enhance bone regeneration --
RN2-00951-1 -- Dopaminergic differentiation of hESCs: developing HTS for drug discovery and non-invasive tools for cell therapy strategy. --
RN2-00953-1 -- Human Limbal Epithelial Stem Cell Conversion into Photoreceptors for Treatment of Retinal Degeneration --
RN2-00954-1 -- Isolation of a homogeneous population of hESC-derived ventricular cardiomyocytes --